Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
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Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut. / Holst, J J; Orskov, C; Nielsen, O V; Schwartz, T W.
I: F E B S Letters, Bind 211, Nr. 2, 1987, s. 169-74.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
AU - Holst, J J
AU - Orskov, C
AU - Nielsen, O V
AU - Schwartz, T W
PY - 1987
Y1 - 1987
N2 - By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.
AB - By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.
KW - Animals
KW - Glucagon
KW - Ileum
KW - Insulin
KW - Intestinal Mucosa
KW - Peptides
KW - Swine
M3 - Journal article
C2 - 3542566
VL - 211
SP - 169
EP - 174
JO - F E B S Letters
JF - F E B S Letters
SN - 0014-5793
IS - 2
ER -
ID: 44293803