The role of milk protein and whey permeate in lipid-based nutrient supplements on the growth and development of stunted children in Uganda: A randomized trial protocol (MAGNUS)
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The role of milk protein and whey permeate in lipid-based nutrient supplements on the growth and development of stunted children in Uganda: A randomized trial protocol (MAGNUS). / Pesu, Hannah; Mutumba, Rolland; Mbabazi, Joseph; Olsen, Mette Frahm; Mølgaard, Christian; Michaelsen, Kim F.; Ritz, Christian; Filteau, Suzanne; Briend, André; Mupere, Ezekiel; Friis, Henrik; Grenov, Benedikte.
I: Current Developments in Nutrition, Bind 5, Nr. 5, nzab067, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The role of milk protein and whey permeate in lipid-based nutrient supplements on the growth and development of stunted children in Uganda: A randomized trial protocol (MAGNUS)
AU - Pesu, Hannah
AU - Mutumba, Rolland
AU - Mbabazi, Joseph
AU - Olsen, Mette Frahm
AU - Mølgaard, Christian
AU - Michaelsen, Kim F.
AU - Ritz, Christian
AU - Filteau, Suzanne
AU - Briend, André
AU - Mupere, Ezekiel
AU - Friis, Henrik
AU - Grenov, Benedikte
N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
PY - 2021
Y1 - 2021
N2 - Stunting is associated with cognitive impairment and later chronic disease. Previous trials to prevent stunting have had little effect, and no trials seem to have provided larger amounts of energy and high-quality proteins to already stunted children. We aimed to assess the effects of milk protein (MP) and whey permeate (WP) in large-quantity lipid-based nutrient supplements (LNS-LQ), among stunted children, on linear growth and child development. This was a randomized, double-blind, 2-by-2 factorial trial. Stunted children aged 12-59 mo from eastern Uganda (n = 750) were randomly assigned to receive 100 g LNS-LQ with or without MP and WP (n = 4 × 150) or no supplement (n = 150) for 3 mo. The primary outcomes were change in knee-heel and total length. Secondary outcomes included child development, body composition, anthropometry, and hemoglobin. Micronutrient status, intestinal function, and microbiota were also assessed. Our findings will contribute to an understanding of the role of milk ingredients and LNS in linear catch-up growth. This trial was registered at www.isrctn.com as ISRCTN13093195.
AB - Stunting is associated with cognitive impairment and later chronic disease. Previous trials to prevent stunting have had little effect, and no trials seem to have provided larger amounts of energy and high-quality proteins to already stunted children. We aimed to assess the effects of milk protein (MP) and whey permeate (WP) in large-quantity lipid-based nutrient supplements (LNS-LQ), among stunted children, on linear growth and child development. This was a randomized, double-blind, 2-by-2 factorial trial. Stunted children aged 12-59 mo from eastern Uganda (n = 750) were randomly assigned to receive 100 g LNS-LQ with or without MP and WP (n = 4 × 150) or no supplement (n = 150) for 3 mo. The primary outcomes were change in knee-heel and total length. Secondary outcomes included child development, body composition, anthropometry, and hemoglobin. Micronutrient status, intestinal function, and microbiota were also assessed. Our findings will contribute to an understanding of the role of milk ingredients and LNS in linear catch-up growth. This trial was registered at www.isrctn.com as ISRCTN13093195.
U2 - 10.1093/cdn/nzab067
DO - 10.1093/cdn/nzab067
M3 - Journal article
C2 - 34027295
VL - 5
JO - Current Developments in Nutrition
JF - Current Developments in Nutrition
SN - 2475-2991
IS - 5
M1 - nzab067
ER -
ID: 269504352