TY - JOUR

T1 - Psychiatric disorders in perinatally HIV-exposed, uninfected children

T2 - a systematic review

AU - Ameri, Sammy

AU - Moseholm, Ellen

AU - Weis, Nina

PY - 2024

Y1 - 2024

N2 - The population of perinatally HIV-exposed but uninfected (HEU) children is growing rapidly globally. However, perinatal HIV and antiretroviral (ARV) medicine exposure in HIV-uninfected children has raised concerns about HEU children's mental well-being. The objective of this study was to systematically review the literature on psychiatric disorders in HEU children. The PRISMA guideline was used as a methodical frame of reference. A systematic search was conducted in 5 databases. Data from the included studies were extracted, and the results were summarized qualitatively. The search identified 1,976 articles of which 105 were eligible for full-text analysis. 13 studies met the inclusion criteria. Eight studies compared psychiatric disorder prevalence in perinatally HIV-infected children with HEU children, and only one study found a difference between the two groups. Three studies found that HEU children had a higher prevalence of psychiatric disorders compared with HIV-unexposed, uninfected (HUU) children. These findings indicate that factors such as psychosocial stress, socioeconomic status, and stigma contribute to the increased risk of mental disorders in HEU children. More research is needed comparing HEU children with HUU children adjusting for potential confounders that might partially explain the higher rates seen in the HIV-exposed population. Prospero ID: CRD42020212420.

AB - The population of perinatally HIV-exposed but uninfected (HEU) children is growing rapidly globally. However, perinatal HIV and antiretroviral (ARV) medicine exposure in HIV-uninfected children has raised concerns about HEU children's mental well-being. The objective of this study was to systematically review the literature on psychiatric disorders in HEU children. The PRISMA guideline was used as a methodical frame of reference. A systematic search was conducted in 5 databases. Data from the included studies were extracted, and the results were summarized qualitatively. The search identified 1,976 articles of which 105 were eligible for full-text analysis. 13 studies met the inclusion criteria. Eight studies compared psychiatric disorder prevalence in perinatally HIV-infected children with HEU children, and only one study found a difference between the two groups. Three studies found that HEU children had a higher prevalence of psychiatric disorders compared with HIV-unexposed, uninfected (HUU) children. These findings indicate that factors such as psychosocial stress, socioeconomic status, and stigma contribute to the increased risk of mental disorders in HEU children. More research is needed comparing HEU children with HUU children adjusting for potential confounders that might partially explain the higher rates seen in the HIV-exposed population. Prospero ID: CRD42020212420.

KW - Children

KW - ART exposure

KW - psychiatric disorder

KW - pediatrics

KW - perinatal HIV exposure

KW - antiretroviral therapy

KW - MENTAL-HEALTH

KW - MITOCHONDRIAL DYSFUNCTION

KW - INFECTED YOUTH

KW - METAANALYSIS

KW - TRANSMISSION

KW - POPULATION

KW - PREVALENCE

KW - METABOLISM

KW - DIAGNOSES

KW - INFANTS

U2 - 10.1080/09540121.2022.2141185

DO - 10.1080/09540121.2022.2141185

M3 - Review

C2 - 36328977

VL - 36

JO - AIDS Care

JF - AIDS Care

SN - 0954-0121

IS - 1

ER -