Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells

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Standard

Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells. / Trinh, Mai Duy Luu; Dinh, Minh-Hiep; Ngo, Dai-Hung; Tran, Dang-Khoa; Tran, Quoc-Tuan; Vo, Thanh-Sang; Ngo, Dai-Nghiep.

I: International Journal of Biological Macromolecules, Bind 66, 09.02.2014, s. 1-6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Trinh, MDL, Dinh, M-H, Ngo, D-H, Tran, D-K, Tran, Q-T, Vo, T-S & Ngo, D-N 2014, 'Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells', International Journal of Biological Macromolecules, bind 66, s. 1-6. https://doi.org/10.1016/j.ijbiomac.2014.01.064

APA

Trinh, M. D. L., Dinh, M-H., Ngo, D-H., Tran, D-K., Tran, Q-T., Vo, T-S., & Ngo, D-N. (2014). Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells. International Journal of Biological Macromolecules, 66, 1-6. https://doi.org/10.1016/j.ijbiomac.2014.01.064

Vancouver

Trinh MDL, Dinh M-H, Ngo D-H, Tran D-K, Tran Q-T, Vo T-S o.a. Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells. International Journal of Biological Macromolecules. 2014 feb. 9;66:1-6. https://doi.org/10.1016/j.ijbiomac.2014.01.064

Author

Trinh, Mai Duy Luu ; Dinh, Minh-Hiep ; Ngo, Dai-Hung ; Tran, Dang-Khoa ; Tran, Quoc-Tuan ; Vo, Thanh-Sang ; Ngo, Dai-Nghiep. / Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells. I: International Journal of Biological Macromolecules. 2014 ; Bind 66. s. 1-6.

Bibtex

@article{3409c82191b14ae78cc3e47e1b1a74dd,
title = "Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells",
abstract = "The aim of this study was to investigate anti-inflammatory activity of 4-hydroxybenzyl-chitooligomers (HB-COS) in Chang liver cells stimulated by a cytokine mixture. It was revealed that HB-COS decreased the level of nitric oxide and prostaglandin E2 (PGE2) production by diminishing the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without significant cytotoxicity. Moreover, HB-COS exerted inhibitory effects on the production of pro-inflammatory mediator (interleukin-6) in Chang liver cells. Notably, HB-COS exhibited anti-inflammatory activities via blocking degradation of inhibitory kappa B alpha (IκB-α), translocation of nuclear factor kappa B (NF-κB), and phosphorylation of mitogen-activated protein kinases (MAPKs) in a dose-dependent manner. Collectively, these findings indicated that HB-COS possessed potential anti-inflammatory effects in Chang liver cells, and could be a useful therapeutic agent for the treatment of hepatic inflammatory diseases.",
keywords = "Faculty of Science, Anti-inflammation, 4-Hydroxybenzyl-chitooligomers, Chang liver cells, iNOS, COX-2",
author = "Trinh, {Mai Duy Luu} and Minh-Hiep Dinh and Dai-Hung Ngo and Dang-Khoa Tran and Quoc-Tuan Tran and Thanh-Sang Vo and Dai-Nghiep Ngo",
year = "2014",
month = feb,
day = "9",
doi = "10.1016/j.ijbiomac.2014.01.064",
language = "English",
volume = "66",
pages = "1--6",
journal = "International Journal of Biological Macromolecules",
issn = "0141-8130",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells

AU - Trinh, Mai Duy Luu

AU - Dinh, Minh-Hiep

AU - Ngo, Dai-Hung

AU - Tran, Dang-Khoa

AU - Tran, Quoc-Tuan

AU - Vo, Thanh-Sang

AU - Ngo, Dai-Nghiep

PY - 2014/2/9

Y1 - 2014/2/9

N2 - The aim of this study was to investigate anti-inflammatory activity of 4-hydroxybenzyl-chitooligomers (HB-COS) in Chang liver cells stimulated by a cytokine mixture. It was revealed that HB-COS decreased the level of nitric oxide and prostaglandin E2 (PGE2) production by diminishing the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without significant cytotoxicity. Moreover, HB-COS exerted inhibitory effects on the production of pro-inflammatory mediator (interleukin-6) in Chang liver cells. Notably, HB-COS exhibited anti-inflammatory activities via blocking degradation of inhibitory kappa B alpha (IκB-α), translocation of nuclear factor kappa B (NF-κB), and phosphorylation of mitogen-activated protein kinases (MAPKs) in a dose-dependent manner. Collectively, these findings indicated that HB-COS possessed potential anti-inflammatory effects in Chang liver cells, and could be a useful therapeutic agent for the treatment of hepatic inflammatory diseases.

AB - The aim of this study was to investigate anti-inflammatory activity of 4-hydroxybenzyl-chitooligomers (HB-COS) in Chang liver cells stimulated by a cytokine mixture. It was revealed that HB-COS decreased the level of nitric oxide and prostaglandin E2 (PGE2) production by diminishing the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without significant cytotoxicity. Moreover, HB-COS exerted inhibitory effects on the production of pro-inflammatory mediator (interleukin-6) in Chang liver cells. Notably, HB-COS exhibited anti-inflammatory activities via blocking degradation of inhibitory kappa B alpha (IκB-α), translocation of nuclear factor kappa B (NF-κB), and phosphorylation of mitogen-activated protein kinases (MAPKs) in a dose-dependent manner. Collectively, these findings indicated that HB-COS possessed potential anti-inflammatory effects in Chang liver cells, and could be a useful therapeutic agent for the treatment of hepatic inflammatory diseases.

KW - Faculty of Science

KW - Anti-inflammation

KW - 4-Hydroxybenzyl-chitooligomers

KW - Chang liver cells

KW - iNOS

KW - COX-2

UR - http://dx.doi.org/10.1016/j.ijbiomac.2014.01.064

U2 - 10.1016/j.ijbiomac.2014.01.064

DO - 10.1016/j.ijbiomac.2014.01.064

M3 - Journal article

VL - 66

SP - 1

EP - 6

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

SN - 0141-8130

ER -

ID: 311345080