TY - JOUR

T1 - PREVIEW: Prevention of diabetes through lifestyle intervention and population studies in Europe and around the world. Design, methods, and baseline participant description of an adult cohort enrolled into a three-year randomised clinical trial

AU - Fogelholm, Mikael

AU - Larsen, Thomas Meinert

AU - Westerterp-Plantenga, Margriet

AU - Macdonald, Ian

AU - Martinez, J Alfredo

AU - Boyadjieva, Nadka

AU - Poppitt, Sally

AU - Schlicht, Wolfgang

AU - Stratton, Gareth

AU - Sundvall, Jouko

AU - Lam, Tony

AU - Jalo, Elli

AU - Christensen, Pia

AU - Drummen, Mathijs

AU - Simpson, Elizabeth M

AU - Navas-Carretero, Santiago

AU - Handjieva-Darlenska, Teodora

AU - Muirhead, Roslyn

AU - Silvestre, Marta P

AU - Kahlert, Daniela

AU - Pastor-Sanz, Laura

AU - Brand-Miller, Jennie

AU - Raben, Anne

N1 - CURIS 2017 NEXS 176

PY - 2017

Y1 - 2017

N2 - Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated. The intervention started with a two-month weight reduction using a low-calorie diet, followed by a randomised 34-month weight maintenance phase comprising four treatment arms. Eight intervention centres are participating (Denmark, Finland, United Kingdom, The Netherlands, Spain, Bulgaria, Australia, and New Zealand). Data from blood specimens, urine, faeces, questionnaires, diaries, body composition assessments, and accelerometers are collected at months 0, 2, 6, 12, 18, 24, and 36. In total, 2326 adults were recruited. The mean age was 51.6 (SD 11.6) years, 67% were women. PREVIEW is, to date, the largest multinational trial to address the prevention of T2D in pre-diabetic adults through diet and exercise intervention. Participants will complete the final intervention in March, 2018.

AB - Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated. The intervention started with a two-month weight reduction using a low-calorie diet, followed by a randomised 34-month weight maintenance phase comprising four treatment arms. Eight intervention centres are participating (Denmark, Finland, United Kingdom, The Netherlands, Spain, Bulgaria, Australia, and New Zealand). Data from blood specimens, urine, faeces, questionnaires, diaries, body composition assessments, and accelerometers are collected at months 0, 2, 6, 12, 18, 24, and 36. In total, 2326 adults were recruited. The mean age was 51.6 (SD 11.6) years, 67% were women. PREVIEW is, to date, the largest multinational trial to address the prevention of T2D in pre-diabetic adults through diet and exercise intervention. Participants will complete the final intervention in March, 2018.

KW - Journal Article

U2 - 10.3390/nu9060632

DO - 10.3390/nu9060632

M3 - Journal article

C2 - 28632180

VL - 9

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 6

M1 - 632

ER -