Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers

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Standard

Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers. / Trinh, Mai Duy Luu; Ngo, Dai-Hung; Tran, Dang-Khoa; Tran, Quoc-Tuan; Vo, Thanh-Sang; Dinh, Minh-Hiep; Ngo, Dai-Nghiep.

I: Carbohydrate Polymers, Bind 103, 27.12.2013, s. 502-509.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Trinh, MDL, Ngo, D-H, Tran, D-K, Tran, Q-T, Vo, T-S, Dinh, M-H & Ngo, D-N 2013, 'Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers', Carbohydrate Polymers, bind 103, s. 502-509. https://doi.org/10.1016/j.carbpol.2013.12.061

APA

Trinh, M. D. L., Ngo, D-H., Tran, D-K., Tran, Q-T., Vo, T-S., Dinh, M-H., & Ngo, D-N. (2013). Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers. Carbohydrate Polymers, 103, 502-509. https://doi.org/10.1016/j.carbpol.2013.12.061

Vancouver

Trinh MDL, Ngo D-H, Tran D-K, Tran Q-T, Vo T-S, Dinh M-H o.a. Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers. Carbohydrate Polymers. 2013 dec. 27;103:502-509. https://doi.org/10.1016/j.carbpol.2013.12.061

Author

Trinh, Mai Duy Luu ; Ngo, Dai-Hung ; Tran, Dang-Khoa ; Tran, Quoc-Tuan ; Vo, Thanh-Sang ; Dinh, Minh-Hiep ; Ngo, Dai-Nghiep. / Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers. I: Carbohydrate Polymers. 2013 ; Bind 103. s. 502-509.

Bibtex

@article{3eb217bf53e146f5a9abb525540047a2,
title = "Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers",
abstract = "In this study, a bioactive derivative of chitooligomers (1.0–3.0 kDa), 4-hydroxybenzyl-COS (HB-COS), was synthesized to enhance antioxidant activity. Hence, HB-COS was evaluated for its capabilities against H2O2-induced oxidative stress in human Chang liver cells. It was found that HB-COS possessed the free radical scavenging activity via decreasing the intracellular reactive oxygen species production. Furthermore, HB-COS significantly reduced the oxidation of DNA in a dose-dependent manner. Notably, HB-COS treatment upregulated the gene and protein expressions of antioxidative enzymes and thereby enhancing the intracellular antioxidant mechanisms. In addition, HB-COS treatment caused a remarkable blockade on degradation of inhibitory kappa B alpha (IκB-α) protein and translocation of nuclear factor kappa B (NF-κB). The current study demonstrated that HB-COS effectively attenuated hydrogen peroxide-induced oxidative stress in Chang liver cells by increasing levels of antioxidant enzymes and inhibiting reactive oxygen species generation, DNA oxidation and the NF-κB signaling pathway.",
keywords = "Faculty of Science, Chang liver cells, 4-Hydroxybenzyl-chitooligomers (HB-COS), Free radical scavenging, Antioxidant enzymes, Nuclear factor kappa B (NF-κB)",
author = "Trinh, {Mai Duy Luu} and Dai-Hung Ngo and Dang-Khoa Tran and Quoc-Tuan Tran and Thanh-Sang Vo and Minh-Hiep Dinh and Dai-Nghiep Ngo",
year = "2013",
month = dec,
day = "27",
doi = "10.1016/j.carbpol.2013.12.061",
language = "English",
volume = "103",
pages = "502--509",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers

AU - Trinh, Mai Duy Luu

AU - Ngo, Dai-Hung

AU - Tran, Dang-Khoa

AU - Tran, Quoc-Tuan

AU - Vo, Thanh-Sang

AU - Dinh, Minh-Hiep

AU - Ngo, Dai-Nghiep

PY - 2013/12/27

Y1 - 2013/12/27

N2 - In this study, a bioactive derivative of chitooligomers (1.0–3.0 kDa), 4-hydroxybenzyl-COS (HB-COS), was synthesized to enhance antioxidant activity. Hence, HB-COS was evaluated for its capabilities against H2O2-induced oxidative stress in human Chang liver cells. It was found that HB-COS possessed the free radical scavenging activity via decreasing the intracellular reactive oxygen species production. Furthermore, HB-COS significantly reduced the oxidation of DNA in a dose-dependent manner. Notably, HB-COS treatment upregulated the gene and protein expressions of antioxidative enzymes and thereby enhancing the intracellular antioxidant mechanisms. In addition, HB-COS treatment caused a remarkable blockade on degradation of inhibitory kappa B alpha (IκB-α) protein and translocation of nuclear factor kappa B (NF-κB). The current study demonstrated that HB-COS effectively attenuated hydrogen peroxide-induced oxidative stress in Chang liver cells by increasing levels of antioxidant enzymes and inhibiting reactive oxygen species generation, DNA oxidation and the NF-κB signaling pathway.

AB - In this study, a bioactive derivative of chitooligomers (1.0–3.0 kDa), 4-hydroxybenzyl-COS (HB-COS), was synthesized to enhance antioxidant activity. Hence, HB-COS was evaluated for its capabilities against H2O2-induced oxidative stress in human Chang liver cells. It was found that HB-COS possessed the free radical scavenging activity via decreasing the intracellular reactive oxygen species production. Furthermore, HB-COS significantly reduced the oxidation of DNA in a dose-dependent manner. Notably, HB-COS treatment upregulated the gene and protein expressions of antioxidative enzymes and thereby enhancing the intracellular antioxidant mechanisms. In addition, HB-COS treatment caused a remarkable blockade on degradation of inhibitory kappa B alpha (IκB-α) protein and translocation of nuclear factor kappa B (NF-κB). The current study demonstrated that HB-COS effectively attenuated hydrogen peroxide-induced oxidative stress in Chang liver cells by increasing levels of antioxidant enzymes and inhibiting reactive oxygen species generation, DNA oxidation and the NF-κB signaling pathway.

KW - Faculty of Science

KW - Chang liver cells

KW - 4-Hydroxybenzyl-chitooligomers (HB-COS)

KW - Free radical scavenging

KW - Antioxidant enzymes

KW - Nuclear factor kappa B (NF-κB)

UR - http://dx.doi.org/10.1016/j.carbpol.2013.12.061

U2 - 10.1016/j.carbpol.2013.12.061

DO - 10.1016/j.carbpol.2013.12.061

M3 - Journal article

VL - 103

SP - 502

EP - 509

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

ER -

ID: 311345666