Muscle ion transporters and antioxidative proteins have different adaptive potential in arm than in leg skeletal muscle with exercise training
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- Mohr et al_Physiological Reports_2017_Vol 5(19)_e13470
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It was evaluated whether upper-body compared to lower-body musculature exhibits a different phenotype in relation to capacity for handling reactive oxygen species (ROS), H(+), La(-), Na(+), K(+) and also whether it differs in adaptive potential to exercise training. Eighty-three sedentary premenopausal women aged 45 ± 6 years (mean ± SD) were randomized into a high-intensity intermittent swimming group (HIS, n = 21), a moderate-intensity swimming group (MOS, n = 21), a soccer group (SOC, n = 21), or a control group (CON, n = 20). Intervention groups completed three weekly training sessions for 15 weeks, and pre- and postintervention biopsies were obtained from deltoideus and vastus lateralis muscle. Before training, monocarboxylate transporter 4 (MCT4), Na(+)/K(+) pump α2, and superoxide dismutase 2 (SOD2) expressions were lower (P < 0.05) in m deltoideus than in m vastus lateralis, whereas deltoid had higher (P < 0.05) Na(+)/H(+) exchanger 1 (NHE1) expression. As a result of training, Na(+)/K(+) pump α2 isoform expression was elevated only in deltoideus muscle, while upregulation (P < 0.05) of the α1 and β1 subunits, phospholemman (FXYD1), NHE1, and superoxide dismutase 1 expression occurred exclusively in vastus lateralis muscle. The increased (P < 0.05) expression of MCT4 and SOD2 in deltoid muscle after HIS and vastus lateralis muscle after SOC were similar. In conclusion, arm musculature displays lower basal ROS, La(-), K(+) handling capability but higher Na(+)-dependent H(+) extrusion capacity than leg musculature. Training-induced changes in the ion-transporting and antioxidant proteins clearly differed between muscle groups.
Originalsprog | Engelsk |
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Artikelnummer | e13470 |
Tidsskrift | Physiological Reports |
Vol/bind | 5 |
Udgave nummer | 19 |
Antal sider | 14 |
ISSN | 2051-817X |
DOI | |
Status | Udgivet - 2017 |
Bibliografisk note
CURIS 2017 NEXS 275
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