Mechanisms of transcription-coupled DNA repair
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Several types of helix-distorting DNA lesions block the passage of elongating RNA polymerase II. Surprisingly, such transcription-blocking lesions are usually repaired considerably faster than non-obstructive lesions in the non-transcribed strand or in the genome overall. In this review, our knowledge of eukaryotic transcription-coupled repair (TCR) will be considered from the point of view of transcription, and current models for the mechanism of TCR will be discussed.
Originalsprog | Engelsk |
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Tidsskrift | Nature Reviews Molecular Cell Biology |
Vol/bind | 3 |
Udgave nummer | 1 |
Sider (fra-til) | 21-29 |
Antal sider | 9 |
ISSN | 1471-0072 |
DOI | |
Status | Udgivet - jan. 2002 |
Eksternt udgivet | Ja |
ID: 331042747