Hydrolysis of Toxic Natural Glucosides Catalyzed by Cyclodextrin Dicyanohydrins

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Standard

Hydrolysis of Toxic Natural Glucosides Catalyzed by Cyclodextrin Dicyanohydrins. / Bjerre, Jeannette; Nielsen, Erik Holm; Bols, Mikael.

I: European Journal of Organic Chemistry, 2008, s. 745-752.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bjerre, J, Nielsen, EH & Bols, M 2008, 'Hydrolysis of Toxic Natural Glucosides Catalyzed by Cyclodextrin Dicyanohydrins', European Journal of Organic Chemistry, s. 745-752. https://doi.org/10.1002/ejoc.200700954

APA

Bjerre, J., Nielsen, E. H., & Bols, M. (2008). Hydrolysis of Toxic Natural Glucosides Catalyzed by Cyclodextrin Dicyanohydrins. European Journal of Organic Chemistry, 745-752. https://doi.org/10.1002/ejoc.200700954

Vancouver

Bjerre J, Nielsen EH, Bols M. Hydrolysis of Toxic Natural Glucosides Catalyzed by Cyclodextrin Dicyanohydrins. European Journal of Organic Chemistry. 2008;745-752. https://doi.org/10.1002/ejoc.200700954

Author

Bjerre, Jeannette ; Nielsen, Erik Holm ; Bols, Mikael. / Hydrolysis of Toxic Natural Glucosides Catalyzed by Cyclodextrin Dicyanohydrins. I: European Journal of Organic Chemistry. 2008 ; s. 745-752.

Bibtex

@article{115afcf0a7e411dcbee902004c4f4f50,
title = "Hydrolysis of Toxic Natural Glucosides Catalyzed by Cyclodextrin Dicyanohydrins",
abstract = "The hydrolysis of toxic 7-hydroxycoumarin glucosides and other aryl and alkyl glucosides, catalyzed by modified a- and {\ss}-cyclodextrin dicyanohydrins, was investigated using different UV, redox, or HPAEC detection assays. The catalyzed reactions all followed Michaelis-Menten kinetics, and an impressive rate increase of up to 7569 (kcat/kuncat) was found for the hydroxycoumarin glucoside substrate 4-MUGP. Good and moderate degrees of catalysis (kcat/kuncat) of up to 1259 were found for the natural glucosides phloridzin and skimmin. By using a newly developed catechol detection UV-assay, a weak degree of catalysis was also found for the toxic hydroxycoumarin esculin. A novel synthesized diaminomethyl {\ss}-cyclodextrin showed a weak catalysis of p-nitrophenyl {\ss}-D-glucopyranoside hydrolysis.",
keywords = "Faculty of Science, Kunstigt Enzym, Supramolekyl{\ae}r Kemi, Glykosidase, Artificial Enzyme, Supramolecular Chemistry, Glycosidase",
author = "Jeannette Bjerre and Nielsen, {Erik Holm} and Mikael Bols",
year = "2008",
doi = "10.1002/ejoc.200700954",
language = "English",
pages = "745--752",
journal = "European Journal of Organic Chemistry",
issn = "1434-193X",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",

}

RIS

TY - JOUR

T1 - Hydrolysis of Toxic Natural Glucosides Catalyzed by Cyclodextrin Dicyanohydrins

AU - Bjerre, Jeannette

AU - Nielsen, Erik Holm

AU - Bols, Mikael

PY - 2008

Y1 - 2008

N2 - The hydrolysis of toxic 7-hydroxycoumarin glucosides and other aryl and alkyl glucosides, catalyzed by modified a- and ß-cyclodextrin dicyanohydrins, was investigated using different UV, redox, or HPAEC detection assays. The catalyzed reactions all followed Michaelis-Menten kinetics, and an impressive rate increase of up to 7569 (kcat/kuncat) was found for the hydroxycoumarin glucoside substrate 4-MUGP. Good and moderate degrees of catalysis (kcat/kuncat) of up to 1259 were found for the natural glucosides phloridzin and skimmin. By using a newly developed catechol detection UV-assay, a weak degree of catalysis was also found for the toxic hydroxycoumarin esculin. A novel synthesized diaminomethyl ß-cyclodextrin showed a weak catalysis of p-nitrophenyl ß-D-glucopyranoside hydrolysis.

AB - The hydrolysis of toxic 7-hydroxycoumarin glucosides and other aryl and alkyl glucosides, catalyzed by modified a- and ß-cyclodextrin dicyanohydrins, was investigated using different UV, redox, or HPAEC detection assays. The catalyzed reactions all followed Michaelis-Menten kinetics, and an impressive rate increase of up to 7569 (kcat/kuncat) was found for the hydroxycoumarin glucoside substrate 4-MUGP. Good and moderate degrees of catalysis (kcat/kuncat) of up to 1259 were found for the natural glucosides phloridzin and skimmin. By using a newly developed catechol detection UV-assay, a weak degree of catalysis was also found for the toxic hydroxycoumarin esculin. A novel synthesized diaminomethyl ß-cyclodextrin showed a weak catalysis of p-nitrophenyl ß-D-glucopyranoside hydrolysis.

KW - Faculty of Science

KW - Kunstigt Enzym

KW - Supramolekylær Kemi

KW - Glykosidase

KW - Artificial Enzyme

KW - Supramolecular Chemistry

KW - Glycosidase

U2 - 10.1002/ejoc.200700954

DO - 10.1002/ejoc.200700954

M3 - Journal article

SP - 745

EP - 752

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

SN - 1434-193X

ER -

ID: 1795623