High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial

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Standard

High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10 : A randomized clinical trial. / Aagaard, Kristina; Jepsen, Jens Richardt Møllegaard; Sevelsted, Astrid; Horner, David; Vinding, Rebecca; Rosenberg, Julie Bøjstrup; Brustad, Nicklas; Eliasen, Anders; Mohammadzadeh, Parisa; Følsgaard, Nilofar; Hernández-lorca, María; Fagerlund, Birgitte; Glenthøj, Birte Y.; Rasmussen, Morten Arendt; Bilenberg, Niels; Stokholm, Jakob; Bønnelykke, Klaus; Ebdrup, Bjørn H.; Chawes, Bo.

I: The American Journal of Clinical Nutrition, Bind 119, Nr. 2, 2024, s. 362-370.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Aagaard, K, Jepsen, JRM, Sevelsted, A, Horner, D, Vinding, R, Rosenberg, JB, Brustad, N, Eliasen, A, Mohammadzadeh, P, Følsgaard, N, Hernández-lorca, M, Fagerlund, B, Glenthøj, BY, Rasmussen, MA, Bilenberg, N, Stokholm, J, Bønnelykke, K, Ebdrup, BH & Chawes, B 2024, 'High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial', The American Journal of Clinical Nutrition, bind 119, nr. 2, s. 362-370. https://doi.org/10.1016/j.ajcnut.2023.12.002

APA

Aagaard, K., Jepsen, J. R. M., Sevelsted, A., Horner, D., Vinding, R., Rosenberg, J. B., Brustad, N., Eliasen, A., Mohammadzadeh, P., Følsgaard, N., Hernández-lorca, M., Fagerlund, B., Glenthøj, B. Y., Rasmussen, M. A., Bilenberg, N., Stokholm, J., Bønnelykke, K., Ebdrup, B. H., & Chawes, B. (2024). High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial. The American Journal of Clinical Nutrition, 119(2), 362-370. https://doi.org/10.1016/j.ajcnut.2023.12.002

Vancouver

Aagaard K, Jepsen JRM, Sevelsted A, Horner D, Vinding R, Rosenberg JB o.a. High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial. The American Journal of Clinical Nutrition. 2024;119(2):362-370. https://doi.org/10.1016/j.ajcnut.2023.12.002

Author

Aagaard, Kristina ; Jepsen, Jens Richardt Møllegaard ; Sevelsted, Astrid ; Horner, David ; Vinding, Rebecca ; Rosenberg, Julie Bøjstrup ; Brustad, Nicklas ; Eliasen, Anders ; Mohammadzadeh, Parisa ; Følsgaard, Nilofar ; Hernández-lorca, María ; Fagerlund, Birgitte ; Glenthøj, Birte Y. ; Rasmussen, Morten Arendt ; Bilenberg, Niels ; Stokholm, Jakob ; Bønnelykke, Klaus ; Ebdrup, Bjørn H. ; Chawes, Bo. / High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10 : A randomized clinical trial. I: The American Journal of Clinical Nutrition. 2024 ; Bind 119, Nr. 2. s. 362-370.

Bibtex

@article{cb015b604c324170b369176268e405cb,
title = "High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial",
abstract = "BackgroundVitamin D deficiency in pregnancy may increase the risk of autism and attention deficit hyperactivity disorder (ADHD).ObjectiveThe objective of this study was to estimate the effect of vitamin D3 supplementation in pregnancy on risk of autism and ADHD.DesignThis randomized clinical trial was part of the COpenhagen Prospective Study on Neuro-PSYCHiatric Development (COPYCH) project nested within the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort comprising a population-based sample of 700 healthy mother-child pairs enrolled at week 24 of pregnancy. Maternal 25-hydroxy-vitamin D (25(OH)D) was measured at inclusion and 623 mothers were randomized 1:1 to either high-dose (2800 IU/d) or standard dose (400 IU/d) vitamin D3 until 1 wk postpartum (315 received high-dose, 308 standard dose). At age 10, diagnoses and symptom load of autism and ADHD, respectively, were established using the Kiddie-Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version.ResultsThe psychopathologic evaluation was completed by 591 children aged 10 y, and 16 children (2.7%) were diagnosed with autism and 65 (11.0%) with ADHD. Hereof, 496 children participated in the vitamin D3 trial (246 received high-dose, 250 standard dose). Of these, 12 children (2.4%) were diagnosed with autism and 58 (11.7%) with ADHD. Higher maternal preintervention 25(OH)D levels were associated with a decreased risk of autism [odd ratio (OR) per 10 nmol/L: 0.76 (0.59,0.97); P = 0.034], lower autistic symptom load [β per 10 nmol/L: −0.03 (−0.05,0.00); P = 0.024), and decreased risk of ADHD diagnosis (OR per 10 nmol/L: 0.88 (0.78,0.99); P = 0.033]. High-dose vitamin D3 supplementation was not associated with risk of autism or ADHD.ConclusionsHigher maternal preintervention 25(OH)D was associated with a decreased risk of autism, lower autistic symptom load, and decreased risk of ADHD diagnosis, but high-dose vitamin D3 supplementation in pregnancy had no effect on risk of autism and ADHD.",
author = "Kristina Aagaard and Jepsen, {Jens Richardt M{\o}llegaard} and Astrid Sevelsted and David Horner and Rebecca Vinding and Rosenberg, {Julie B{\o}jstrup} and Nicklas Brustad and Anders Eliasen and Parisa Mohammadzadeh and Nilofar F{\o}lsgaard and Mar{\'i}a Hern{\'a}ndez-lorca and Birgitte Fagerlund and Glenth{\o}j, {Birte Y.} and Rasmussen, {Morten Arendt} and Niels Bilenberg and Jakob Stokholm and Klaus B{\o}nnelykke and Ebdrup, {Bj{\o}rn H.} and Bo Chawes",
year = "2024",
doi = "10.1016/j.ajcnut.2023.12.002",
language = "English",
volume = "119",
pages = "362--370",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "2",

}

RIS

TY - JOUR

T1 - High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10

T2 - A randomized clinical trial

AU - Aagaard, Kristina

AU - Jepsen, Jens Richardt Møllegaard

AU - Sevelsted, Astrid

AU - Horner, David

AU - Vinding, Rebecca

AU - Rosenberg, Julie Bøjstrup

AU - Brustad, Nicklas

AU - Eliasen, Anders

AU - Mohammadzadeh, Parisa

AU - Følsgaard, Nilofar

AU - Hernández-lorca, María

AU - Fagerlund, Birgitte

AU - Glenthøj, Birte Y.

AU - Rasmussen, Morten Arendt

AU - Bilenberg, Niels

AU - Stokholm, Jakob

AU - Bønnelykke, Klaus

AU - Ebdrup, Bjørn H.

AU - Chawes, Bo

PY - 2024

Y1 - 2024

N2 - BackgroundVitamin D deficiency in pregnancy may increase the risk of autism and attention deficit hyperactivity disorder (ADHD).ObjectiveThe objective of this study was to estimate the effect of vitamin D3 supplementation in pregnancy on risk of autism and ADHD.DesignThis randomized clinical trial was part of the COpenhagen Prospective Study on Neuro-PSYCHiatric Development (COPYCH) project nested within the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort comprising a population-based sample of 700 healthy mother-child pairs enrolled at week 24 of pregnancy. Maternal 25-hydroxy-vitamin D (25(OH)D) was measured at inclusion and 623 mothers were randomized 1:1 to either high-dose (2800 IU/d) or standard dose (400 IU/d) vitamin D3 until 1 wk postpartum (315 received high-dose, 308 standard dose). At age 10, diagnoses and symptom load of autism and ADHD, respectively, were established using the Kiddie-Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version.ResultsThe psychopathologic evaluation was completed by 591 children aged 10 y, and 16 children (2.7%) were diagnosed with autism and 65 (11.0%) with ADHD. Hereof, 496 children participated in the vitamin D3 trial (246 received high-dose, 250 standard dose). Of these, 12 children (2.4%) were diagnosed with autism and 58 (11.7%) with ADHD. Higher maternal preintervention 25(OH)D levels were associated with a decreased risk of autism [odd ratio (OR) per 10 nmol/L: 0.76 (0.59,0.97); P = 0.034], lower autistic symptom load [β per 10 nmol/L: −0.03 (−0.05,0.00); P = 0.024), and decreased risk of ADHD diagnosis (OR per 10 nmol/L: 0.88 (0.78,0.99); P = 0.033]. High-dose vitamin D3 supplementation was not associated with risk of autism or ADHD.ConclusionsHigher maternal preintervention 25(OH)D was associated with a decreased risk of autism, lower autistic symptom load, and decreased risk of ADHD diagnosis, but high-dose vitamin D3 supplementation in pregnancy had no effect on risk of autism and ADHD.

AB - BackgroundVitamin D deficiency in pregnancy may increase the risk of autism and attention deficit hyperactivity disorder (ADHD).ObjectiveThe objective of this study was to estimate the effect of vitamin D3 supplementation in pregnancy on risk of autism and ADHD.DesignThis randomized clinical trial was part of the COpenhagen Prospective Study on Neuro-PSYCHiatric Development (COPYCH) project nested within the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort comprising a population-based sample of 700 healthy mother-child pairs enrolled at week 24 of pregnancy. Maternal 25-hydroxy-vitamin D (25(OH)D) was measured at inclusion and 623 mothers were randomized 1:1 to either high-dose (2800 IU/d) or standard dose (400 IU/d) vitamin D3 until 1 wk postpartum (315 received high-dose, 308 standard dose). At age 10, diagnoses and symptom load of autism and ADHD, respectively, were established using the Kiddie-Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version.ResultsThe psychopathologic evaluation was completed by 591 children aged 10 y, and 16 children (2.7%) were diagnosed with autism and 65 (11.0%) with ADHD. Hereof, 496 children participated in the vitamin D3 trial (246 received high-dose, 250 standard dose). Of these, 12 children (2.4%) were diagnosed with autism and 58 (11.7%) with ADHD. Higher maternal preintervention 25(OH)D levels were associated with a decreased risk of autism [odd ratio (OR) per 10 nmol/L: 0.76 (0.59,0.97); P = 0.034], lower autistic symptom load [β per 10 nmol/L: −0.03 (−0.05,0.00); P = 0.024), and decreased risk of ADHD diagnosis (OR per 10 nmol/L: 0.88 (0.78,0.99); P = 0.033]. High-dose vitamin D3 supplementation was not associated with risk of autism or ADHD.ConclusionsHigher maternal preintervention 25(OH)D was associated with a decreased risk of autism, lower autistic symptom load, and decreased risk of ADHD diagnosis, but high-dose vitamin D3 supplementation in pregnancy had no effect on risk of autism and ADHD.

U2 - 10.1016/j.ajcnut.2023.12.002

DO - 10.1016/j.ajcnut.2023.12.002

M3 - Journal article

C2 - 38072183

VL - 119

SP - 362

EP - 370

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 2

ER -

ID: 379586560