Fast-twitch glycolytic skeletal muscle is predisposed to age-induced impairments in mitochondrial function
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The etiology of mammalian senescence is suggested to involve the progressive impairment of mitochondrial function; however, direct observations of age-induced alterations in actual respiratory chain function are lacking. Accordingly, we assessed mitochondrial function via high-resolution respirometry and mitochondrial protein expression in soleus, quadricep, and lateral gastrocnemius skeletal muscles, which represent type 1 slow-twitch oxidative muscle (soleus) and type 2 fast-twitch glycolytic muscle (quadricep and gastrocnemius), respectively, in young (10-12 weeks) and mature (74-76 weeks) mice. Electron transport through mitochondrial complexes I and III increases with age in quadricep and gastrocnemius, which is not observed in soleus. Mitochondrial coupling efficiency during respiration through complex I also deteriorates with age in gastrocnemius and shows a tendency (p = .085) to worsen in quadricep. These data demonstrate actual alterations in electron transport function that occurs with age and are dependent on skeletal muscle type.
Originalsprog | Engelsk |
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Tidsskrift | Journals of Gerontology. Series A: Biological Sciences & Medical Sciences |
Vol/bind | 68 |
Udgave nummer | 9 |
Sider (fra-til) | 1010-1022 |
Antal sider | 12 |
ISSN | 1079-5006 |
DOI | |
Status | Udgivet - 2013 |
Bibliografisk note
CURIS 2013 NEXS 100
ID: 45708004