Exercise training improves blood flow to contracting skeletal muscle of older men via enhanced cGMP signaling
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Exercise training improves blood flow to contracting skeletal muscle of older men via enhanced cGMP signaling. / Piil, Peter Bergmann; Smith Jørgensen, Tue; Egelund, Jon; Damsgaard, Rasmus; Gliemann, Lasse; Hellsten, Ylva; Nyberg, Michael Permin.
I: Journal of Applied Physiology, Bind 124, Nr. 1, 2018, s. 109-117.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Exercise training improves blood flow to contracting skeletal muscle of older men via enhanced cGMP signaling
AU - Piil, Peter Bergmann
AU - Smith Jørgensen, Tue
AU - Egelund, Jon
AU - Damsgaard, Rasmus
AU - Gliemann, Lasse
AU - Hellsten, Ylva
AU - Nyberg, Michael Permin
N1 - CURIS 2018 NEXS 044
PY - 2018
Y1 - 2018
N2 - Physical activity has the potential to offset age-related impairments in the regulation of blood flow and O2 delivery to the exercising muscles; however, the mechanisms underlying this effect of physical activity remain poorly understood. The present study examined the role of cGMP in training-induced adaptations in the regulation of skeletal muscle blood flow and oxidative metabolism during exercise in aging humans. We measured leg hemodynamics and oxidative metabolism during exercise engaging the knee-extensor muscles in young (n=15, 25 ± 1 years) and older (n=15, 72 ± 1 years) subjects before and after a period of aerobic high-intensity exercise training. To determine the role of cGMP signaling, pharmacological inhibition of phosphodiesterase 5 (PDE5) was performed. Before training, inhibition of PDE5 increased (P<0.05) skeletal muscle blood flow and VO2 during moderate-intensity exercise in the older group; however, these effects of PDE5 inhibition were not detected after training. These findings suggest a role for enhanced cGMP signaling in the training-induced improvement of regulation of blood flow in contracting skeletal muscle of older men.
AB - Physical activity has the potential to offset age-related impairments in the regulation of blood flow and O2 delivery to the exercising muscles; however, the mechanisms underlying this effect of physical activity remain poorly understood. The present study examined the role of cGMP in training-induced adaptations in the regulation of skeletal muscle blood flow and oxidative metabolism during exercise in aging humans. We measured leg hemodynamics and oxidative metabolism during exercise engaging the knee-extensor muscles in young (n=15, 25 ± 1 years) and older (n=15, 72 ± 1 years) subjects before and after a period of aerobic high-intensity exercise training. To determine the role of cGMP signaling, pharmacological inhibition of phosphodiesterase 5 (PDE5) was performed. Before training, inhibition of PDE5 increased (P<0.05) skeletal muscle blood flow and VO2 during moderate-intensity exercise in the older group; however, these effects of PDE5 inhibition were not detected after training. These findings suggest a role for enhanced cGMP signaling in the training-induced improvement of regulation of blood flow in contracting skeletal muscle of older men.
KW - Aging
KW - Exercise hyperemia
KW - Oxidative metabolism
KW - PDE5
KW - Phosphodiesterase 5
U2 - 10.1152/japplphysiol.00634.2017
DO - 10.1152/japplphysiol.00634.2017
M3 - Journal article
C2 - 28982945
VL - 124
SP - 109
EP - 117
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 1
ER -
ID: 184390794