TY - JOUR

T1 - Effect of protein or essential amino acid supplementation during prolonged resistance exercise training in older adults on body composition, muscle strength, and physical performance parameters

T2 - A systematic review

AU - Gade Bang-Petersen, Josephine

AU - Pedersen, Rie Johanne

AU - Beck, Anne Marie

N1 - "Ekstern" publikation!

PY - 2018

Y1 - 2018

N2 - Objectives: Loss of muscle mass and strength with aging, sarcopenia, burdens many older adults, making identification of strategies on how to counteract it very relevant—especially to health care providers working in rehabilitation. The aim of this systematic review was to determine the effect of protein or essential amino acid (EAA) supplementation during prolonged resistance exercise training (RT) in older adults. No known stimulants of muscle protein synthesis, or ingredients with an effect on muscle strength/physical function, were allowedwith the supplementation, differentiating this systematic review from others.Data sources and methods: In January 2017, 4 electronic databases and reference lists were searched for randomized controlled trials investigating the effect of protein or EAA supplementation during RT in older adults (mean age >60 years) on outcomes of body composition, muscle strength, and physical performance. Study selection and data extraction were performed by 2 independent reviewers.Results: Sixteen studies (1107 participants) fulfilled the eligibility criteria. Methodologic differences between the studies disallowed a meta-analysis. Of the 16 studies, 6 found significant effects on body composition (3 studies), muscle strength (3 studies), and physical performance (2 studies) measures.Conclusions: The evidence is weak and inconsistent, as benefit of protein or EAA supplementation during RT in older adults is only shown in some studies. The findings indicate that frail/sarcopenic older adults might benefit more than healthy older adults. Further research is needed to allow an interpretation on the importance of study population and design.Trial registration: PROSPERO, Reg. no.: CRD42017063808. Registered April 14, 2017.

AB - Objectives: Loss of muscle mass and strength with aging, sarcopenia, burdens many older adults, making identification of strategies on how to counteract it very relevant—especially to health care providers working in rehabilitation. The aim of this systematic review was to determine the effect of protein or essential amino acid (EAA) supplementation during prolonged resistance exercise training (RT) in older adults. No known stimulants of muscle protein synthesis, or ingredients with an effect on muscle strength/physical function, were allowedwith the supplementation, differentiating this systematic review from others.Data sources and methods: In January 2017, 4 electronic databases and reference lists were searched for randomized controlled trials investigating the effect of protein or EAA supplementation during RT in older adults (mean age >60 years) on outcomes of body composition, muscle strength, and physical performance. Study selection and data extraction were performed by 2 independent reviewers.Results: Sixteen studies (1107 participants) fulfilled the eligibility criteria. Methodologic differences between the studies disallowed a meta-analysis. Of the 16 studies, 6 found significant effects on body composition (3 studies), muscle strength (3 studies), and physical performance (2 studies) measures.Conclusions: The evidence is weak and inconsistent, as benefit of protein or EAA supplementation during RT in older adults is only shown in some studies. The findings indicate that frail/sarcopenic older adults might benefit more than healthy older adults. Further research is needed to allow an interpretation on the importance of study population and design.Trial registration: PROSPERO, Reg. no.: CRD42017063808. Registered April 14, 2017.

KW - Faculty of Science

KW - Resistance exercise training

KW - Nutrition

KW - Older adult's health care

KW - Rehabilitation

KW - Systematic review

U2 - 10.1177/1179572718765760

DO - 10.1177/1179572718765760

M3 - Review

VL - 7

SP - 1

EP - 12

JO - Rehabilitation Process and Outcome

JF - Rehabilitation Process and Outcome

SN - 1179-5727

ER -