Disease course and treatment outcomes of Crohn's disease patients with early or late surgery: A Danish nationwide cohort study from 1997 to 2015
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Disease course and treatment outcomes of Crohn's disease patients with early or late surgery : A Danish nationwide cohort study from 1997 to 2015. / Sarikaya, M. Z.; Zhao, M.; Lo, B.; Bendtsen, F.; Burisch, J.
I: Digestive and Liver Disease, Bind 55, Nr. 7, 2023, s. 872-879.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Disease course and treatment outcomes of Crohn's disease patients with early or late surgery
T2 - A Danish nationwide cohort study from 1997 to 2015
AU - Sarikaya, M. Z.
AU - Zhao, M.
AU - Lo, B.
AU - Bendtsen, F.
AU - Burisch, J.
N1 - Publisher Copyright: © 2022
PY - 2023
Y1 - 2023
N2 - Background: Studies on early surgery among Crohn's disease patients are few and focus on ileocolonic resections. Aim: The aim of this nationwide cohort study was to investigate the disease course in all Crohn's disease patients who underwent early and late major abdominal surgery. Methods: In a Danish nationwide cohort of Crohn's disease patients from 1997 to 2015 we included 493 patients (group 1) resected within 29 days, 472 patients (group 2) resected between 30 and 180 days, and 1,518 patients (group 3) resected after 180 days of diagnosis. Re-operation, hospitalisations and medications were analysed. Results: The cumulative risk of re-operation was lower among patients from group 1 (five-year risk: 16.5% vs. group 2: 18.2% and group 3: 21.2%, p = 0.004). Fewer patients from group 2 and 3 required hospitalisations (269 (56.5%) and 803 (52.8%) vs. group 1: 329 (66.8%) p<0.001). Patients from group 3 had a higher cumulative use of immunomodulators in the first three years after initial surgery (one-year risk: 24.6% vs. group 1: 19.4% and group 2: 17.0%, p<0.001). Conclusion: Crohn's disease patients resected within 29 days of diagnosis had a lower cumulative risk of re-operation and a lower cumulative exposure to immunomodulators in the initial years after surgery.
AB - Background: Studies on early surgery among Crohn's disease patients are few and focus on ileocolonic resections. Aim: The aim of this nationwide cohort study was to investigate the disease course in all Crohn's disease patients who underwent early and late major abdominal surgery. Methods: In a Danish nationwide cohort of Crohn's disease patients from 1997 to 2015 we included 493 patients (group 1) resected within 29 days, 472 patients (group 2) resected between 30 and 180 days, and 1,518 patients (group 3) resected after 180 days of diagnosis. Re-operation, hospitalisations and medications were analysed. Results: The cumulative risk of re-operation was lower among patients from group 1 (five-year risk: 16.5% vs. group 2: 18.2% and group 3: 21.2%, p = 0.004). Fewer patients from group 2 and 3 required hospitalisations (269 (56.5%) and 803 (52.8%) vs. group 1: 329 (66.8%) p<0.001). Patients from group 3 had a higher cumulative use of immunomodulators in the first three years after initial surgery (one-year risk: 24.6% vs. group 1: 19.4% and group 2: 17.0%, p<0.001). Conclusion: Crohn's disease patients resected within 29 days of diagnosis had a lower cumulative risk of re-operation and a lower cumulative exposure to immunomodulators in the initial years after surgery.
KW - Crohn
KW - IBD
KW - Surgery
U2 - 10.1016/j.dld.2022.09.016
DO - 10.1016/j.dld.2022.09.016
M3 - Journal article
C2 - 36266208
AN - SCOPUS:85140322433
VL - 55
SP - 872
EP - 879
JO - Rendiconti di Gastro-Enterologia
JF - Rendiconti di Gastro-Enterologia
SN - 1590-8658
IS - 7
ER -
ID: 343128533