Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention: A controlled post-hoc trial

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Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention: A controlled post-hoc trial. / Navas-Carretero, Santiago; San-Cristobal, Rodrigo; Vestentoft, Pia Siig; Brand-Miller, Jennie C.; Jalo, Elli; Westerterp-Plantenga, Margriet; Simpson, Elizabeth J; Handjieva-Darlenska, Teodora; Stratton, Gareth; Huttunen-Lenz, Maija; Lam, Tony; Muirhead, Roslyn; Poppitt, Sally; Pietiläinen, Kirsi H; Adam, Tanja; Taylor, Moira A; Handjiev, Svetoslav; McNarry, Melitta A; Hansen, Sylvia; Brodie, Shannon; Silvestre, Marta P; Macdonald, Ian A; Boyadjieva, Nadka; Mackintosh, Kelly A; Schlicht, Wolfgang; Liu, Amy; Larsen, Thomas Meinert; Fogelholm, Mikael; Raben, Anne; Martinez, J Alfredo.

I: Frontiers in Nutrition, Bind 8, 733697, 2021.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Navas-Carretero, S, San-Cristobal, R, Vestentoft, PS, Brand-Miller, JC, Jalo, E, Westerterp-Plantenga, M, Simpson, EJ, Handjieva-Darlenska, T, Stratton, G, Huttunen-Lenz, M, Lam, T, Muirhead, R, Poppitt, S, Pietiläinen, KH, Adam, T, Taylor, MA, Handjiev, S, McNarry, MA, Hansen, S, Brodie, S, Silvestre, MP, Macdonald, IA, Boyadjieva, N, Mackintosh, KA, Schlicht, W, Liu, A, Larsen, TM, Fogelholm, M, Raben, A & Martinez, JA 2021, 'Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention: A controlled post-hoc trial', Frontiers in Nutrition, bind 8, 733697. https://doi.org/10.3389/fnut.2021.733697

APA

Navas-Carretero, S., San-Cristobal, R., Vestentoft, P. S., Brand-Miller, J. C., Jalo, E., Westerterp-Plantenga, M., Simpson, E. J., Handjieva-Darlenska, T., Stratton, G., Huttunen-Lenz, M., Lam, T., Muirhead, R., Poppitt, S., Pietiläinen, K. H., Adam, T., Taylor, M. A., Handjiev, S., McNarry, M. A., Hansen, S., ... Martinez, J. A. (2021). Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention: A controlled post-hoc trial. Frontiers in Nutrition, 8, [733697]. https://doi.org/10.3389/fnut.2021.733697

Vancouver

Navas-Carretero S, San-Cristobal R, Vestentoft PS, Brand-Miller JC, Jalo E, Westerterp-Plantenga M o.a. Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention: A controlled post-hoc trial. Frontiers in Nutrition. 2021;8. 733697. https://doi.org/10.3389/fnut.2021.733697

Author

Navas-Carretero, Santiago ; San-Cristobal, Rodrigo ; Vestentoft, Pia Siig ; Brand-Miller, Jennie C. ; Jalo, Elli ; Westerterp-Plantenga, Margriet ; Simpson, Elizabeth J ; Handjieva-Darlenska, Teodora ; Stratton, Gareth ; Huttunen-Lenz, Maija ; Lam, Tony ; Muirhead, Roslyn ; Poppitt, Sally ; Pietiläinen, Kirsi H ; Adam, Tanja ; Taylor, Moira A ; Handjiev, Svetoslav ; McNarry, Melitta A ; Hansen, Sylvia ; Brodie, Shannon ; Silvestre, Marta P ; Macdonald, Ian A ; Boyadjieva, Nadka ; Mackintosh, Kelly A ; Schlicht, Wolfgang ; Liu, Amy ; Larsen, Thomas Meinert ; Fogelholm, Mikael ; Raben, Anne ; Martinez, J Alfredo. / Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention: A controlled post-hoc trial. I: Frontiers in Nutrition. 2021 ; Bind 8.

Bibtex

@article{557fdc77d8094ddd8128273507b97848,
title = "Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention: A controlled post-hoc trial",
abstract = "Background: Individuals with pre-diabetes are commonly overweight andbenefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs.Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers,and diet and exercise questionnaires under standardized procedures.Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity.Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D.Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01777893reference, identifier: NCT01777893.",
keywords = "Faculty of Science, Obesity, Pre-diabetes, Triglycerides (PubChem CID: 5460048), Hypertriglyceridemic-waist phenotype, Precision nutrition, Diabetes, Carbohydrate metabolism, Lipid markers",
author = "Santiago Navas-Carretero and Rodrigo San-Cristobal and Vestentoft, {Pia Siig} and Brand-Miller, {Jennie C.} and Elli Jalo and Margriet Westerterp-Plantenga and Simpson, {Elizabeth J} and Teodora Handjieva-Darlenska and Gareth Stratton and Maija Huttunen-Lenz and Tony Lam and Roslyn Muirhead and Sally Poppitt and Pietil{\"a}inen, {Kirsi H} and Tanja Adam and Taylor, {Moira A} and Svetoslav Handjiev and McNarry, {Melitta A} and Sylvia Hansen and Shannon Brodie and Silvestre, {Marta P} and Macdonald, {Ian A} and Nadka Boyadjieva and Mackintosh, {Kelly A} and Wolfgang Schlicht and Amy Liu and Larsen, {Thomas Meinert} and Mikael Fogelholm and Anne Raben and Martinez, {J Alfredo}",
note = "CURIS 2021 NEXS 340",
year = "2021",
doi = "10.3389/fnut.2021.733697",
language = "English",
volume = "8",
journal = "Frontiers in Nutrition",
issn = "2296-861X",
publisher = "Frontiers",

}

RIS

TY - JOUR

T1 - Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention: A controlled post-hoc trial

AU - Navas-Carretero, Santiago

AU - San-Cristobal, Rodrigo

AU - Vestentoft, Pia Siig

AU - Brand-Miller, Jennie C.

AU - Jalo, Elli

AU - Westerterp-Plantenga, Margriet

AU - Simpson, Elizabeth J

AU - Handjieva-Darlenska, Teodora

AU - Stratton, Gareth

AU - Huttunen-Lenz, Maija

AU - Lam, Tony

AU - Muirhead, Roslyn

AU - Poppitt, Sally

AU - Pietiläinen, Kirsi H

AU - Adam, Tanja

AU - Taylor, Moira A

AU - Handjiev, Svetoslav

AU - McNarry, Melitta A

AU - Hansen, Sylvia

AU - Brodie, Shannon

AU - Silvestre, Marta P

AU - Macdonald, Ian A

AU - Boyadjieva, Nadka

AU - Mackintosh, Kelly A

AU - Schlicht, Wolfgang

AU - Liu, Amy

AU - Larsen, Thomas Meinert

AU - Fogelholm, Mikael

AU - Raben, Anne

AU - Martinez, J Alfredo

N1 - CURIS 2021 NEXS 340

PY - 2021

Y1 - 2021

N2 - Background: Individuals with pre-diabetes are commonly overweight andbenefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs.Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers,and diet and exercise questionnaires under standardized procedures.Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity.Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D.Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01777893reference, identifier: NCT01777893.

AB - Background: Individuals with pre-diabetes are commonly overweight andbenefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs.Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers,and diet and exercise questionnaires under standardized procedures.Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity.Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D.Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01777893reference, identifier: NCT01777893.

KW - Faculty of Science

KW - Obesity

KW - Pre-diabetes

KW - Triglycerides (PubChem CID: 5460048)

KW - Hypertriglyceridemic-waist phenotype

KW - Precision nutrition

KW - Diabetes

KW - Carbohydrate metabolism

KW - Lipid markers

U2 - 10.3389/fnut.2021.733697

DO - 10.3389/fnut.2021.733697

M3 - Journal article

C2 - 34790686

VL - 8

JO - Frontiers in Nutrition

JF - Frontiers in Nutrition

SN - 2296-861X

M1 - 733697

ER -

ID: 284422807