TY - JOUR

T1 - AMPK in skeletal muscle function and metabolism

AU - Kjøbsted, Rasmus

AU - Hingst, Janne Rasmuss

AU - Fentz, Joachim

AU - Foretz, Marc

AU - Sanz, Maria-Nieves

AU - Pehmøller, Christian

AU - Shum, Michael

AU - Marette, André

AU - Mounier, Remi

AU - Treebak, Jonas Thue

AU - Wojtaszewski, Jørgen

AU - Viollet, Benoit

AU - Lantier, Louise

N1 - CURIS 2018 NEXS 110

PY - 2018

Y1 - 2018

N2 - Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning anabolic and catabolic pathways. AMPK's role as an energy sensor is particularly critical in tissues displaying highly changeable energy turnover. Due to the drastic changes in energy demand that occur between the resting and exercising state, skeletal muscle is one such tissue. Here, we review the complex regulation of AMPK in skeletal muscle and its consequences on metabolism (e.g., substrate uptake, oxidation, and storage as well as mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK in skeletal muscle during exercise and in exercise recovery. We also address adaptations to exercise training, including skeletal muscle plasticity, highlighting novel concepts and future perspectives that need to be investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic target as well as different AMPK activators and their potential for future drug development.-Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M, Sanz, M.-N., Pehmøller, C., Shum, M., Marette, A., Mounier, R., Treebak, J. T., Wojtaszewski, J. F. P., Viollet, B., Lantier, L. AMPK in skeletal muscle function and metabolism.

AB - Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning anabolic and catabolic pathways. AMPK's role as an energy sensor is particularly critical in tissues displaying highly changeable energy turnover. Due to the drastic changes in energy demand that occur between the resting and exercising state, skeletal muscle is one such tissue. Here, we review the complex regulation of AMPK in skeletal muscle and its consequences on metabolism (e.g., substrate uptake, oxidation, and storage as well as mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK in skeletal muscle during exercise and in exercise recovery. We also address adaptations to exercise training, including skeletal muscle plasticity, highlighting novel concepts and future perspectives that need to be investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic target as well as different AMPK activators and their potential for future drug development.-Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M, Sanz, M.-N., Pehmøller, C., Shum, M., Marette, A., Mounier, R., Treebak, J. T., Wojtaszewski, J. F. P., Viollet, B., Lantier, L. AMPK in skeletal muscle function and metabolism.

KW - Exercise

KW - Mitochondria

KW - Glucose uptake

KW - Plasticity

KW - Diabetes

U2 - 10.1096/fj.201700442R

DO - 10.1096/fj.201700442R

M3 - Review

C2 - 29242278

VL - 32

SP - 1741

EP - 1777

JO - F A S E B Journal

JF - F A S E B Journal

SN - 0892-6638

IS - 4

ER -