Amphotericin B and the blood-brain barrier to methotrexate
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The permeability of the blood-brain barrier (BBB) to methotrexate, Na+, and Cl- was studied in rats treated with the membrane-active antifungal agent amphotericin B. Enhancement of brain uptake of methotrexate was expected as amphotericin B increases the permeability of lipid membranes, including tumor cell membranes. However, amphotericin B had no effect of the BBB permeability to methotrexate, Na+, and Cl-. This may have been because the amphotericin B acted only on the luminal and not on the abluminal brain capillary membrane, leaving the BBB intact.
Originalsprog | Engelsk |
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Tidsskrift | Neurosurgery |
Vol/bind | 10 |
Udgave nummer | 2 |
Sider (fra-til) | 224-6 |
Antal sider | 3 |
ISSN | 0148-396X |
Status | Udgivet - feb. 1982 |
ID: 279596784