Deuterium dilution technique for body composition assessment: resolving methodological issues in children with moderate acute malnutrition
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Deuterium dilution technique for body composition assessment: resolving methodological issues in children with moderate acute malnutrition. / Fabiansen, Christian; Yaméogo, Charles W; Devi, Sarita; Friis, Henrik; Kurpad, Anura; Wells, Jonathan C.
In: Isotopes in Environmental and Health Studies, Vol. 53, No. 4, 2017, p. 344-355.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Deuterium dilution technique for body composition assessment: resolving methodological issues in children with moderate acute malnutrition
AU - Fabiansen, Christian
AU - Yaméogo, Charles W
AU - Devi, Sarita
AU - Friis, Henrik
AU - Kurpad, Anura
AU - Wells, Jonathan C
N1 - CURIS 2017 NEXS 090
PY - 2017
Y1 - 2017
N2 - Childhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques.
AB - Childhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques.
KW - Body composition
KW - Children
KW - Deuterium dilution
KW - Malnutrition
KW - Tracer technique
KW - Saliva sampling
KW - Equlilbration time
U2 - 10.1080/10256016.2017.1295043
DO - 10.1080/10256016.2017.1295043
M3 - Journal article
C2 - 28276731
VL - 53
SP - 344
EP - 355
JO - Isotopes in Environmental and Health Studies
JF - Isotopes in Environmental and Health Studies
SN - 1025-6016
IS - 4
ER -
ID: 174400834