The August Krogh Section for Molecular Physiology
The August Krogh Section for Molecular Physiology conducts research aimed at developing in-depth knowledge regarding metabolic regulation in relation to physical activity, nutrition, and health.
The August Krogh Section for Molecular Physiology uses advanced molecular biological methods in combination with genetically modified animals and special human populations to conduct ground breaking research that spans from man to molecule.
Research is carried out from ‘molecule to man’, and uses molecular biological techniques, genetically modified animals and healthy and health-compromised people in the research. The vision is that observations based on experiments conducted in people can be explained at the molecular level, and similarly that mechanistic basic research in the laboratory can lead to new findings, that can be transferred to the human organism and the population.
For example, the section investigates:
- Molecular mechanisms that regulate carbohydrate and fat metabolism during exercise.
- Regulation of insulin sensitivity after physical activity and inactivity (and the role of diet in this context).
- Interplay between physical activity and diet on performance and health parameters.
- How physical activity combined with different diets affects metabolism, insulin sensitivity, and gene expression in men and women.
Selected publications from the section
Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function. Blazev R, Carl CS, Ng YK, Molendijk J, Voldstedlund CT, Zhao Y, Xiao D, Kueh AJ, Miotto PM, Haynes VR, Hardee JP, Chung JD, McNamara JW, Qian H, Gregorevic P, Oakhill JS, Herold MJ, Jensen TE, Lisowski L, Lynch GS, Dodd GT, Watt MJ, Yang P, Kiens B, Richter EA, Parker BL. Cell Metab. 2022 Oct 4;34(10):1561-1577.e9. Epub 2022 Jul 25.
Personalized phosphoproteomics identifies functional signaling. Needham EJ, Hingst JR, Parker BL, Morrison KR, Yang G, Onslev J, Kristensen JM, Højlund K, Ling NXY, Oakhill JS, Richter EA, Kiens B, Petersen J, Pehmøller C, James DE, Wojtaszewski JFP, Humphrey SJ. Nat Biotechnol. 2022 Apr;40(4):576-584. Epub 2021 Dec 2.
TBC1D4-S711 controls skeletal muscle insulin sensitization after exercise and contraction. Rasmus Kjøbsted; Jonas M. Kristensen; Nicolas O. Eskesen; Kohei Kido; Klara Fjorder; Ditte F. Damgaard; Jeppe K. Larsen; Nicoline R. Andersen; Jesper B. Birk; Anders Gudiksen; Jonas T. Treebak; Peter Schjerling; Henriette Pilegaard; Jørgen F. P. Wojtaszewski. Diabetes.
Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle. Jonas R Knudsen Is a corresponding author, Kaspar W Persson, Carlos Henriquez-Olguin, Zhencheng Li, Nicolas Di Leo, Sofie A Hesselager, Steffen H Raun, Janne R Hingst, Raphaël Trouillon, Martin Wohlwend, Jørgen FP Wojtaszewski, Martin AM Gijs, Thomas Elbenhardt Jensen. Elife.
AXIN1 knockout does not alter AMPK/mTORC1 regulation and glucose metabolism in mouse skeletal muscle
Li, J., Knudsen, Jonas Roland, Henriquez Olguín, Carlos, Li, Z., Birk, Jesper Bratz, Persson, K. W., Hellsten, Ylva, Offergeld, A., Jarassier, W., Grand, F. L., Schjerling, P., Wojtaszewski, Jørgen F P & Jensen, Thomas Elbenhardt, 2021, I: Journal of Physiology. 599, 12, s. 3081-3100 20 s.
Head of section: Professor Jørgen Wojtaszewski
Section Research Coordinator: Kate Wickham
Visiting address
The August Krogh Section for Molecular Physiology
Department of Nutrition, Exercise and Sports
Universitetsparken 13
DK 2100 Copenhagen
Denmark
Postal address
Department of Nutrition, Exercise and Sports
The August Krogh Section for Molecular Physiology
Nørre Allé 51
DK 2200 Copenhagen N
Denmark
Section members
Name | Title | Phone | |
---|---|---|---|
Search in Name | Search in Title | Search in Phone | |
Amalie London | PhD Student | ||
Annemarie Lundsgaard | Assistant Professor | +4535321755 | |
Aslak Emil Lyster | PhD Fellow | +4535333692 | |
Bente Kiens | Professor | +4535321619 | |
Betina Bolmgren | Biomedical Laboratory Scientist | +4535321748 | |
Carlos Henriquez Olguín | Postdoc | ||
Casper Møller Sigvardsen | Research Assistant | +4535324780 | |
Christian Strini Carl | Postdoc | ||
Christian Thomas Voldstedlund | PhD Fellow | +4535325095 | |
Elise Needham | Guest Researcher | ||
Erik A. Richter | Professor | +4535321626 | |
Farina Leonie Schlabs | Visiting Student | ||
Irene Bech Nielsen | Biomedical Laboratory Scientist | +4535321752 | |
Jakob Krøll Jensen | Research Assistant | ||
Jesper Bratz Birk | Academic Staff | +4535321613 | |
Johan Dejgaard Onslev | Postdoc | ||
Jonas Roland Knudsen | Postdoc | ||
Josephine Maria Kanta | PhD Fellow | ||
Jørgen Wojtaszewski | Professor, Head of Section | +4535321625 | |
Kaspar Wredstrøm Persson | PhD Fellow | +4535320305 | |
Liljana Diskovska | Cleaning Assistant | +4535321574 | |
Louise Slot Christiansen | Postdoc | +4535324818 | |
Lykke Sylow | Visiting Associate Professor | +4535321767 | |
Magnus Romme Leandersson | PhD Fellow | +4535320766 | |
Maximilian Kleinert | Assistant Professor | +4535321769 | |
Nicki Winfield Almquist | Postdoc | +4535336083 | |
Nicolai Stevns Henriksen | Academic Research Staff | +4535325071 | |
Nicolas Oldenburg Eskesen | Postdoc | +4535333826 | |
Nicoline Resen Andersen | Academic Staff | +4535321765 | |
Nicoline Vilhelmine Vestergaard | Guest Researcher | ||
Nikolaj Winther | Research Assistant | +4535326604 | |
Rasmus Kjøbsted | Assistant Professor | +4535321764 | |
Roberto Andrés Meneses Valdés | PhD Student | ||
Samantha Alicia Gallero San Martín | Research Assistant | ||
Thomas Elbenhardt Jensen | Associate Professor | +4535321757 | |
Trine Sand Nicolaisen | Research Assistant |