The August Krogh Section for Molecular Physiology

Research is carried out from ‘molecule to man’, and uses molecular biological techniques, genetically modified animals and healthy and health-compromised people in the research. The vision is that observations based on experiments conducted in people can be explained at the molecular level, and similarly that mechanistic basic research in the laboratory can lead to new findings, that can be transferred to the human organism and the population.

For example, the section investigates:

• Molecular mechanisms that regulate carbohydrate and fat metabolism during exercise.
• Regulation of insulin sensitivity after physical activity and inactivity (and the role of diet in this context).
• Interplay between physical activity and diet on performance and health parameters.
• How physical activity combined with different diets affects metabolism, insulin sensitivity, and gene expression in men and women.

Selected publications from the section

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function. Blazev R, Carl CS, Ng YK, Molendijk J, Voldstedlund CT, Zhao Y, Xiao D, Kueh AJ, Miotto PM, Haynes VR, Hardee JP, Chung JD, McNamara JW, Qian H, Gregorevic P, Oakhill JS, Herold MJ, Jensen TE, Lisowski L, Lynch GS, Dodd GT, Watt MJ, Yang P, Kiens B, Richter EA, Parker BL. Cell Metab. 2022 Oct 4;34(10):1561-1577.e9. Epub 2022 Jul 25.

Personalized phosphoproteomics identifies functional signaling. Needham EJ, Hingst JR, Parker BL, Morrison KR, Yang G, Onslev J, Kristensen JM, Højlund K, Ling NXY, Oakhill JS, Richter EA, Kiens B, Petersen J, Pehmøller C, James DE, Wojtaszewski JFP, Humphrey SJ. Nat Biotechnol. 2022 Apr;40(4):576-584. Epub 2021 Dec 2.

TBC1D4-S711 controls skeletal muscle insulin sensitization after exercise and contraction. Rasmus Kjøbsted; Jonas M. Kristensen; Nicolas O. Eskesen; Kohei Kido; Klara Fjorder; Ditte F. Damgaard; Jeppe K. Larsen; Nicoline R. Andersen; Jesper B. Birk; Anders Gudiksen; Jonas T. Treebak; Peter Schjerling; Henriette Pilegaard; Jørgen F. P. Wojtaszewski. Diabetes.

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle. Jonas R Knudsen Is a corresponding author, Kaspar W Persson, Carlos Henriquez-Olguin, Zhencheng Li, Nicolas Di Leo, Sofie A Hesselager, Steffen H Raun, Janne R Hingst, Raphaël Trouillon, Martin Wohlwend, Jørgen FP Wojtaszewski, Martin AM Gijs, Thomas Elbenhardt Jensen. Elife.

AXIN1 knockout does not alter AMPK/mTORC1 regulation and glucose metabolism in mouse skeletal muscle
Li, J., Knudsen, Jonas Roland, Henriquez Olguín, Carlos, Li, Z., Birk, Jesper Bratz, Persson, K. W., Hellsten, Ylva, Offergeld, A., Jarassier, W., Grand, F. L., Schjerling, P., Wojtaszewski, Jørgen F P & Jensen, Thomas Elbenhardt, 2021, I: Journal of Physiology. 599, 12, s. 3081-3100 20 s.

See all the publications from the section.

Head of section: Professor Jørgen Wojtaszewski

Section Research Coordinator: Kate Wickham

Visiting address
The August Krogh Section for Molecular Physiology
Department of Nutrition, Exercise and Sports
Universitetsparken 13
DK 2100 Copenhagen
Denmark

Postal address
Department of Nutrition, Exercise and Sports
The August Krogh Section for Molecular Physiology
Nørre Allé 51
DK 2200 Copenhagen N
Denmark

See overview map of North Campus

Plan your trip