Weight-for-height z-score gain during inpatient and subsequent linear growth during outpatient treatment of young children with severe acute malnutrition, a prospective study from Uganda
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Weight-for-height z-score gain during inpatient and subsequent linear growth during outpatient treatment of young children with severe acute malnutrition, a prospective study from Uganda. / Kamugisha, Jolly General Katebarirwe; Lanyero, Betty; Nabukeera-Barungi, Nicolette; Ritz, Christian; Mølgaard, Christian; Michaelsen, Kim F.; Briend, André; Mupere, Ezekiel; Friis, Henrik; Grenov, Benedikte.
In: Current Developments in Nutrition, Vol. 5, No. 10, nzab118, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Weight-for-height z-score gain during inpatient and subsequent linear growth during outpatient treatment of young children with severe acute malnutrition, a prospective study from Uganda
AU - Kamugisha, Jolly General Katebarirwe
AU - Lanyero, Betty
AU - Nabukeera-Barungi, Nicolette
AU - Ritz, Christian
AU - Mølgaard, Christian
AU - Michaelsen, Kim F.
AU - Briend, André
AU - Mupere, Ezekiel
AU - Friis, Henrik
AU - Grenov, Benedikte
N1 - CURIS 2021 NEXS 322
PY - 2021
Y1 - 2021
N2 - Background: Linear catch-up growth after treatment of severe acute malnutrition (SAM) is low, and little is known about the association between ponderal and subsequent linear growth.Objective: The study assessed the association of weight-for-height z-score (WHZ) gain with subsequent linear growth during SAM treatment and examined its modifiers.Methods: This was a prospective study, nested in a trial (ISRCTN16454889), among 6-59-mo-old children treated for SAM in Uganda. Weight, total length (TL) and knee-heel length (KHL) were measured at admission, weekly during inpatient-therapeutic-care (ITC), at discharge and fortnightly during outpatient-therapeutic-care (OTC) for 8 weeks. Linear regression was used to assess theassociation between WHZ gain during ITC and linear growth during OTC.Results: Of 400 children, 327 were discharged to OTC and 290 followed-up for 8 weeks. Mean WHZ gains were 0.45 in ITC and 1.24 in OTC, whereas mean height-for-age z-score (HAZ) declined 0.41 during ITC and increased 0.14 during OTC. WHZ gain during ITC was positively associated with HAZ, TL and KHL gains during OTC (regression coefficients (b) [95% CI]: (0.12 [0.09; 0.15] z-score; 3.1 [2.4; 3.8] mm; 0.5 [0.1; 0.7] mm). The regression coefficients were highest for the middle tertile of WHZ gain with respect to HAZ and TL. Admission diarrhea and low plasma citrulline reduced the association between WHZ gain during ITC and HAZ and TL gain during OTC (P<0.001). In contrast, pneumonia (P=0.051) and elevated plasma CRP (P<0.001) increased the association with TL gain, but reduced the association with KHL gain (P<0.001).Conclusion: Among children admitted with SAM, considerable WHZ gain during ITC was followed by very modest linear catch-up growth during OTC, with no indication of a WHZ gain threshold, above which linear growth was higher. To optimize linear growth in these children, early treatment of infections and conditions affecting the gut may be necessary.
AB - Background: Linear catch-up growth after treatment of severe acute malnutrition (SAM) is low, and little is known about the association between ponderal and subsequent linear growth.Objective: The study assessed the association of weight-for-height z-score (WHZ) gain with subsequent linear growth during SAM treatment and examined its modifiers.Methods: This was a prospective study, nested in a trial (ISRCTN16454889), among 6-59-mo-old children treated for SAM in Uganda. Weight, total length (TL) and knee-heel length (KHL) were measured at admission, weekly during inpatient-therapeutic-care (ITC), at discharge and fortnightly during outpatient-therapeutic-care (OTC) for 8 weeks. Linear regression was used to assess theassociation between WHZ gain during ITC and linear growth during OTC.Results: Of 400 children, 327 were discharged to OTC and 290 followed-up for 8 weeks. Mean WHZ gains were 0.45 in ITC and 1.24 in OTC, whereas mean height-for-age z-score (HAZ) declined 0.41 during ITC and increased 0.14 during OTC. WHZ gain during ITC was positively associated with HAZ, TL and KHL gains during OTC (regression coefficients (b) [95% CI]: (0.12 [0.09; 0.15] z-score; 3.1 [2.4; 3.8] mm; 0.5 [0.1; 0.7] mm). The regression coefficients were highest for the middle tertile of WHZ gain with respect to HAZ and TL. Admission diarrhea and low plasma citrulline reduced the association between WHZ gain during ITC and HAZ and TL gain during OTC (P<0.001). In contrast, pneumonia (P=0.051) and elevated plasma CRP (P<0.001) increased the association with TL gain, but reduced the association with KHL gain (P<0.001).Conclusion: Among children admitted with SAM, considerable WHZ gain during ITC was followed by very modest linear catch-up growth during OTC, with no indication of a WHZ gain threshold, above which linear growth was higher. To optimize linear growth in these children, early treatment of infections and conditions affecting the gut may be necessary.
KW - Faculty of Science
KW - Stunting
KW - Linear growth
KW - Severe acute nutrition
KW - Children
KW - Uganda
UR - https://doi.org/10.1093/cdn/nzab118
U2 - 10.1093/cdn/nzab118
DO - 10.1093/cdn/nzab118
M3 - Journal article
C2 - 34712895
VL - 5
JO - Current Developments in Nutrition
JF - Current Developments in Nutrition
SN - 2475-2991
IS - 10
M1 - nzab118
ER -
ID: 280609116