The impact of zinc supplementation on Schistosoma mansoni reinfection rate and intensities: a randomized, controlled trial among rural Zimbabwean schoolchildren
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The impact of zinc supplementation on Schistosoma mansoni reinfection rate and intensities : a randomized, controlled trial among rural Zimbabwean schoolchildren. / Friis, Henrik; Ndhlovu, P; Mduluza, T; Kaondera, K; Sandström, B; Michaelsen, Kim F.; Vennervald, Birgitte J; Ørnbjerg, Niels.
In: European Journal of Clinical Nutrition, Vol. 51, No. 1, 1997, p. 33-37.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The impact of zinc supplementation on Schistosoma mansoni reinfection rate and intensities
T2 - a randomized, controlled trial among rural Zimbabwean schoolchildren
AU - Friis, Henrik
AU - Ndhlovu, P
AU - Mduluza, T
AU - Kaondera, K
AU - Sandström, B
AU - Michaelsen, Kim F.
AU - Vennervald, Birgitte J
AU - Ørnbjerg, Niels
PY - 1997
Y1 - 1997
N2 - OBJECTIVES: To assess the effect of zinc supplementation on susceptibility to S. mansoni reinfections among schoolchildren.DESIGN: Randomized, double-blind, placebo-controlled trial.SETTING AND SUBJECTS: 313 rural Zimbabwean schoolchildren (144 boys and 169 girls), 11-17 y).INTERVENTIONS: Supplementation with zinc (30 or 50 mg) or placebo on schooldays for 12 months. Due to drought, a food programme was in operation during the last eight months of the study.OUTCOME MEASURES: S. mansoni and S. haematobium reinfection rates and intensities.RESULTS: There was no difference in reinfection rates between the zinc and placebo groups (25 vs 29%, P = 0.46). However, the median intensity of S. mansoni reinfection, although low in both groups, was significantly lower in the zinc than in the placebo group (7 vs 13 eggs per gram of faeces, P = 0.048). No difference in either S. haematobium reinfection rates or intensities were seen.CONCLUSIONS: Zinc supplementation reduced the intensity of S. mansoni reinfections. Although the intensities of reinfection were very low, the finding probably reflects a biological effect of zinc that could be of public health importance in settings with higher transmission.
AB - OBJECTIVES: To assess the effect of zinc supplementation on susceptibility to S. mansoni reinfections among schoolchildren.DESIGN: Randomized, double-blind, placebo-controlled trial.SETTING AND SUBJECTS: 313 rural Zimbabwean schoolchildren (144 boys and 169 girls), 11-17 y).INTERVENTIONS: Supplementation with zinc (30 or 50 mg) or placebo on schooldays for 12 months. Due to drought, a food programme was in operation during the last eight months of the study.OUTCOME MEASURES: S. mansoni and S. haematobium reinfection rates and intensities.RESULTS: There was no difference in reinfection rates between the zinc and placebo groups (25 vs 29%, P = 0.46). However, the median intensity of S. mansoni reinfection, although low in both groups, was significantly lower in the zinc than in the placebo group (7 vs 13 eggs per gram of faeces, P = 0.048). No difference in either S. haematobium reinfection rates or intensities were seen.CONCLUSIONS: Zinc supplementation reduced the intensity of S. mansoni reinfections. Although the intensities of reinfection were very low, the finding probably reflects a biological effect of zinc that could be of public health importance in settings with higher transmission.
KW - Adolescent
KW - Child
KW - Disease Susceptibility
KW - Double-Blind Method
KW - Female
KW - Humans
KW - Male
KW - Patient Compliance
KW - Placebos
KW - Recurrence
KW - Schistosomiasis mansoni
KW - Zimbabwe
KW - Zinc
M3 - Journal article
C2 - 9023465
VL - 51
SP - 33
EP - 37
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
IS - 1
ER -
ID: 119654602