PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results

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PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years : Design, methods and baseline results. / Dorenbos, Elke; Drummen, Mathijs; Rijks, Jesse; Adam, Tanja; Stouthart, Pauline; Martínez, J Alfredo; Navas-Carretero, Santiago; Stratton, Gareth; Swindell, Nils; Fogelholm, Mikael; Raben, Anne; Westerterp-Plantenga, Margriet; Vreugdenhil, Anita.

In: Diabetes, Obesity and Metabolism, Vol. 20, No. 5, 2018, p. 1096-1101.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dorenbos, E, Drummen, M, Rijks, J, Adam, T, Stouthart, P, Martínez, JA, Navas-Carretero, S, Stratton, G, Swindell, N, Fogelholm, M, Raben, A, Westerterp-Plantenga, M & Vreugdenhil, A 2018, 'PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results', Diabetes, Obesity and Metabolism, vol. 20, no. 5, pp. 1096-1101. https://doi.org/10.1111/dom.13216

APA

Dorenbos, E., Drummen, M., Rijks, J., Adam, T., Stouthart, P., Martínez, J. A., Navas-Carretero, S., Stratton, G., Swindell, N., Fogelholm, M., Raben, A., Westerterp-Plantenga, M., & Vreugdenhil, A. (2018). PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results. Diabetes, Obesity and Metabolism, 20(5), 1096-1101. https://doi.org/10.1111/dom.13216

Vancouver

Dorenbos E, Drummen M, Rijks J, Adam T, Stouthart P, Martínez JA et al. PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results. Diabetes, Obesity and Metabolism. 2018;20(5):1096-1101. https://doi.org/10.1111/dom.13216

Author

Dorenbos, Elke ; Drummen, Mathijs ; Rijks, Jesse ; Adam, Tanja ; Stouthart, Pauline ; Martínez, J Alfredo ; Navas-Carretero, Santiago ; Stratton, Gareth ; Swindell, Nils ; Fogelholm, Mikael ; Raben, Anne ; Westerterp-Plantenga, Margriet ; Vreugdenhil, Anita. / PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years : Design, methods and baseline results. In: Diabetes, Obesity and Metabolism. 2018 ; Vol. 20, No. 5. pp. 1096-1101.

Bibtex

@article{a254deadad2747f2a67766f92728011e,
title = "PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results",
abstract = "Insulin resistance (IR) in adolescence is associated with T2DM. The PREVIEW study assesses the effectiveness of a high-protein, low-glycaemic index diet and moderate-protein, moderate-glycaemic index diet to decrease IR in insulin resistant children with overweight/obesity. Inclusion criteria were age 10-17y, HOMA-IR≥2.0 and overweight/obesity. In 126 children (13.6±2.2y, BMI z-score 3.04±0.66, HOMA-IR 3.48±2.28) anthropometrics, fat mass percentage (FM%), metabolic parameters, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41±1.86 vs. 3.23±1.86, p=0.007) and prepubertal and pubertal children with overweight/obesity (vs. 3.61±1.60, p=0.004 and vs. 3.40±1.50, p<0.001 respectively). IR was associated with sex, Tanner stage, BMI z-score, and FM%. Fasting glucose concentrations were negatively associated with Baecke Sport (r=-0.223, p=0.025) and positively with daytime sleepiness (r=0.280, p=0.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The relations between fasting glucose concentration with Baecke Sport and sleepiness suggest these might be possible targets for diabetes prevention.",
keywords = "Dietary intervention, Insulin resistance, Radomized trial, Type 2 diabetes",
author = "Elke Dorenbos and Mathijs Drummen and Jesse Rijks and Tanja Adam and Pauline Stouthart and Mart{\'i}nez, {J Alfredo} and Santiago Navas-Carretero and Gareth Stratton and Nils Swindell and Mikael Fogelholm and Anne Raben and Margriet Westerterp-Plantenga and Anita Vreugdenhil",
note = "CURIS 2018 NEXS 062",
year = "2018",
doi = "10.1111/dom.13216",
language = "English",
volume = "20",
pages = "1096--1101",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years

T2 - Design, methods and baseline results

AU - Dorenbos, Elke

AU - Drummen, Mathijs

AU - Rijks, Jesse

AU - Adam, Tanja

AU - Stouthart, Pauline

AU - Martínez, J Alfredo

AU - Navas-Carretero, Santiago

AU - Stratton, Gareth

AU - Swindell, Nils

AU - Fogelholm, Mikael

AU - Raben, Anne

AU - Westerterp-Plantenga, Margriet

AU - Vreugdenhil, Anita

N1 - CURIS 2018 NEXS 062

PY - 2018

Y1 - 2018

N2 - Insulin resistance (IR) in adolescence is associated with T2DM. The PREVIEW study assesses the effectiveness of a high-protein, low-glycaemic index diet and moderate-protein, moderate-glycaemic index diet to decrease IR in insulin resistant children with overweight/obesity. Inclusion criteria were age 10-17y, HOMA-IR≥2.0 and overweight/obesity. In 126 children (13.6±2.2y, BMI z-score 3.04±0.66, HOMA-IR 3.48±2.28) anthropometrics, fat mass percentage (FM%), metabolic parameters, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41±1.86 vs. 3.23±1.86, p=0.007) and prepubertal and pubertal children with overweight/obesity (vs. 3.61±1.60, p=0.004 and vs. 3.40±1.50, p<0.001 respectively). IR was associated with sex, Tanner stage, BMI z-score, and FM%. Fasting glucose concentrations were negatively associated with Baecke Sport (r=-0.223, p=0.025) and positively with daytime sleepiness (r=0.280, p=0.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The relations between fasting glucose concentration with Baecke Sport and sleepiness suggest these might be possible targets for diabetes prevention.

AB - Insulin resistance (IR) in adolescence is associated with T2DM. The PREVIEW study assesses the effectiveness of a high-protein, low-glycaemic index diet and moderate-protein, moderate-glycaemic index diet to decrease IR in insulin resistant children with overweight/obesity. Inclusion criteria were age 10-17y, HOMA-IR≥2.0 and overweight/obesity. In 126 children (13.6±2.2y, BMI z-score 3.04±0.66, HOMA-IR 3.48±2.28) anthropometrics, fat mass percentage (FM%), metabolic parameters, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41±1.86 vs. 3.23±1.86, p=0.007) and prepubertal and pubertal children with overweight/obesity (vs. 3.61±1.60, p=0.004 and vs. 3.40±1.50, p<0.001 respectively). IR was associated with sex, Tanner stage, BMI z-score, and FM%. Fasting glucose concentrations were negatively associated with Baecke Sport (r=-0.223, p=0.025) and positively with daytime sleepiness (r=0.280, p=0.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The relations between fasting glucose concentration with Baecke Sport and sleepiness suggest these might be possible targets for diabetes prevention.

KW - Dietary intervention

KW - Insulin resistance

KW - Radomized trial

KW - Type 2 diabetes

U2 - 10.1111/dom.13216

DO - 10.1111/dom.13216

M3 - Journal article

C2 - 29322617

VL - 20

SP - 1096

EP - 1101

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 5

ER -

ID: 188447449