Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids: A Preview study
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Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids : A Preview study. / Tischmann, Lea; Drummen, Mathijs; Gatta-Cherifi, Blandine; Raben, Anne; Fogelholm, Mikael; Hartmann, Bolette; Holst, Jens Juul; Matias, Isabelle; Cota, Daniela; Mensink, Ronald P; Peters, Joris; Westerterp-Plantenga, Margriet S; Adam, Tanja C.
In: Nutrients, Vol. 11, 2269, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids
T2 - A Preview study
AU - Tischmann, Lea
AU - Drummen, Mathijs
AU - Gatta-Cherifi, Blandine
AU - Raben, Anne
AU - Fogelholm, Mikael
AU - Hartmann, Bolette
AU - Holst, Jens Juul
AU - Matias, Isabelle
AU - Cota, Daniela
AU - Mensink, Ronald P
AU - Peters, Joris
AU - Westerterp-Plantenga, Margriet S
AU - Adam, Tanja C
N1 - CURIS 2019 NEXS 305
PY - 2019
Y1 - 2019
N2 - Favorable eects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body weight management have been shown. To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. At approximately 34 months after weight loss, 22 female and 16 male participants (mean age 64.5 5.9 years; body mass index (BMI) 28.9 3.9 kg/m2) completed a 48 h respiration chamber study. Participants were fed in energy balance with a HP/MCHO diet with 25%:45%:30% or a moderate-protein/high-carbohydrate (MP/HCHO) diet with 15%:55%:30% of energy from protein:carbohydrate:fat. Endocannabinoids and related compounds, relevant postprandial hormones (GLP-1, PYY), hunger, satiety, and ad libitum food intake were assessed. HP/MCHO versus MP/HCHO reduced hunger perception. The lower decremental area under the curve (dAUC) for hunger in the HP/MCHO diet (−56.6% compared to MP, p < 0.05) was associated with the higher AUC for 2-arachidonoylglycerol (2-AG) concentrations (p < 0.05). Hunger was inversely associated with PYY in the HP/MCHO group (r = −0.7, p < 0.01). Ad libitum food intake, homeostatic model assessment for insulin resistance (HOMA-IR) and incremental AUCs for gut peptides were not different between conditions. HP/MCHO versus MP/HCHO diet-induced reduction in hunger was present after 34 months weight maintenance in the post-obese state. HP/MCHO diet-induced decrease of hunger is suggested to interact with increased 2-AG and PYY concentrations.
AB - Favorable eects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body weight management have been shown. To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. At approximately 34 months after weight loss, 22 female and 16 male participants (mean age 64.5 5.9 years; body mass index (BMI) 28.9 3.9 kg/m2) completed a 48 h respiration chamber study. Participants were fed in energy balance with a HP/MCHO diet with 25%:45%:30% or a moderate-protein/high-carbohydrate (MP/HCHO) diet with 15%:55%:30% of energy from protein:carbohydrate:fat. Endocannabinoids and related compounds, relevant postprandial hormones (GLP-1, PYY), hunger, satiety, and ad libitum food intake were assessed. HP/MCHO versus MP/HCHO reduced hunger perception. The lower decremental area under the curve (dAUC) for hunger in the HP/MCHO diet (−56.6% compared to MP, p < 0.05) was associated with the higher AUC for 2-arachidonoylglycerol (2-AG) concentrations (p < 0.05). Hunger was inversely associated with PYY in the HP/MCHO group (r = −0.7, p < 0.01). Ad libitum food intake, homeostatic model assessment for insulin resistance (HOMA-IR) and incremental AUCs for gut peptides were not different between conditions. HP/MCHO versus MP/HCHO diet-induced reduction in hunger was present after 34 months weight maintenance in the post-obese state. HP/MCHO diet-induced decrease of hunger is suggested to interact with increased 2-AG and PYY concentrations.
KW - Faculty of Science
KW - Protein
KW - Endocannabinoids
KW - Hunger
KW - Satiety
KW - Gut peptides
KW - Weight maintenance
KW - Obesity
U2 - 10.3390/nu11102269
DO - 10.3390/nu11102269
M3 - Journal article
C2 - 31546629
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
M1 - 2269
ER -
ID: 227696323