Dimetikon ved laktuloseinduceret dyspepsi. Effekt på H2-produktion og symptomer
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Dimetikon ved laktuloseinduceret dyspepsi. Effekt på H2-produktion og symptomer. / Friis, Henrik; Bodé, S H; Rumessen, J J; Gudmand-Høyer, E.
In: Ugeskrift for Laeger, Vol. 155, No. 42, 1993, p. 3378-3380.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dimetikon ved laktuloseinduceret dyspepsi. Effekt på H2-produktion og symptomer
AU - Friis, Henrik
AU - Bodé, S H
AU - Rumessen, J J
AU - Gudmand-Høyer, E
N1 - Inviteret dobbeltpublication
PY - 1993
Y1 - 1993
N2 - The results of studies of the effect of simethicone on abdominal gas-related symptoms have been contradictory. In a randomized, double-blind, cross-over study, ten healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo. End-expiratory breath samples were collected and analyzed for H2, and gastrointestinal symptoms registered. There were no differences in biochemical parameters or symptom score between simethicone and placebo. In contrast to previous studies, we used a sufficiently large dose of lactulose to produce gastrointestinal symptoms, a higher dose of simethicone and placebo tablets containing the same additives as the simethicone tablets. There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption.
AB - The results of studies of the effect of simethicone on abdominal gas-related symptoms have been contradictory. In a randomized, double-blind, cross-over study, ten healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo. End-expiratory breath samples were collected and analyzed for H2, and gastrointestinal symptoms registered. There were no differences in biochemical parameters or symptom score between simethicone and placebo. In contrast to previous studies, we used a sufficiently large dose of lactulose to produce gastrointestinal symptoms, a higher dose of simethicone and placebo tablets containing the same additives as the simethicone tablets. There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption.
KW - Adolescent
KW - Adult
KW - Double-Blind Method
KW - Dyspepsia
KW - Female
KW - Gases
KW - Humans
KW - Hydrogen
KW - Intestines
KW - Lactulose
KW - Male
KW - Simethicone
M3 - Tidsskriftartikel
C2 - 8259628
VL - 155
SP - 3378
EP - 3380
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 42
ER -
ID: 119653996