TY - JOUR

T1 - Towards nutrition with precision

T2 - unlocking biomarkers as dietary assessment tools

AU - Cuparencu, Cătălina

AU - Bulmuş-Tüccar, Tuğçe

AU - Stanstrup, Jan

AU - La Barbera, Giorgia

AU - Roager, Henrik M.

AU - Dragsted, Lars O.

N1 - Publisher Copyright: © Springer Nature Limited 2024.

PY - 2024

Y1 - 2024

N2 - Precision nutrition requires precise tools to monitor dietary habits. Yet current dietary assessment instruments are subjective, limiting our understanding of the causal relationships between diet and health. Biomarkers of food intake (BFIs) hold promise to increase the objectivity and accuracy of dietary assessment, enabling adjustment for compliance and misreporting. Here, we update current concepts and provide a comprehensive overview of BFIs measured in urine and blood. We rank BFIs based on a four-level utility scale to guide selection and identify combinations of BFIs that specifically reflect complex food intakes, making them applicable as dietary instruments. We discuss the main challenges in biomarker development and illustrate key solutions for the application of BFIs in human studies, highlighting different strategies for selecting and combining BFIs to support specific study designs. Finally, we present a roadmap for BFI development and implementation to leverage current knowledge and enable precision in nutrition research.

AB - Precision nutrition requires precise tools to monitor dietary habits. Yet current dietary assessment instruments are subjective, limiting our understanding of the causal relationships between diet and health. Biomarkers of food intake (BFIs) hold promise to increase the objectivity and accuracy of dietary assessment, enabling adjustment for compliance and misreporting. Here, we update current concepts and provide a comprehensive overview of BFIs measured in urine and blood. We rank BFIs based on a four-level utility scale to guide selection and identify combinations of BFIs that specifically reflect complex food intakes, making them applicable as dietary instruments. We discuss the main challenges in biomarker development and illustrate key solutions for the application of BFIs in human studies, highlighting different strategies for selecting and combining BFIs to support specific study designs. Finally, we present a roadmap for BFI development and implementation to leverage current knowledge and enable precision in nutrition research.

U2 - 10.1038/s42255-024-01067-y

DO - 10.1038/s42255-024-01067-y

M3 - Review

C2 - 38956322

AN - SCOPUS:85197469245

JO - Nature Metabolism

JF - Nature Metabolism

SN - 2522-5812

ER -