Serum carotenoids and macular pigment optical density in patients with intestinal resections and healthy subjects: an exploratory study
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Serum carotenoids and macular pigment optical density in patients with intestinal resections and healthy subjects: an exploratory study. / Eriksen, Jane Nygaard; Prahm, August P; Falk, Mads Krüger; Arrigoni, Eva; Jeppesen, Palle Bekker; Larsen, Michael; Dragsted, Lars Ove.
In: Journal of Nutritional Science, Vol. 7, e8, 2018.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - Serum carotenoids and macular pigment optical density in patients with intestinal resections and healthy subjects: an exploratory study
AU - Eriksen, Jane Nygaard
AU - Prahm, August P
AU - Falk, Mads Krüger
AU - Arrigoni, Eva
AU - Jeppesen, Palle Bekker
AU - Larsen, Michael
AU - Dragsted, Lars Ove
N1 - CURIS 2018 NEXS 055
PY - 2018
Y1 - 2018
N2 - Reduced absorption capacity in patients with intestinal resections (IR) could result in malabsorption of fat-soluble components like carotenoids, which are of clinical interest in relation to visual health. In this case cohort, we investigated the association between IR and serum lutein, zeaxanthin, β-carotene and macular pigment optical density, when compared with healthy controls. Ten patients with IR and twelve healthy controls were included in the study. Baseline characteristics were comparable between groups, except for higher serum TAG (P < 0·05) and shorter bowel length (P < 0·0001) in the group with IR. Serum lutein, zeaxanthin, β-carotene and macular pigment optical density were >15 % lower in the patient group compared with healthy controls (P < 0·05, adjusted for age) and, in the case of serum lutein and zeaxanthin, also for dietary intake of carotenoids. Results suggest that for a test of macular carotenoid supplementation, subjects with a potentially clinically significant carotenoid deficit could be recruited among patients with IR.
AB - Reduced absorption capacity in patients with intestinal resections (IR) could result in malabsorption of fat-soluble components like carotenoids, which are of clinical interest in relation to visual health. In this case cohort, we investigated the association between IR and serum lutein, zeaxanthin, β-carotene and macular pigment optical density, when compared with healthy controls. Ten patients with IR and twelve healthy controls were included in the study. Baseline characteristics were comparable between groups, except for higher serum TAG (P < 0·05) and shorter bowel length (P < 0·0001) in the group with IR. Serum lutein, zeaxanthin, β-carotene and macular pigment optical density were >15 % lower in the patient group compared with healthy controls (P < 0·05, adjusted for age) and, in the case of serum lutein and zeaxanthin, also for dietary intake of carotenoids. Results suggest that for a test of macular carotenoid supplementation, subjects with a potentially clinically significant carotenoid deficit could be recruited among patients with IR.
KW - Faculty of Science
KW - Lutein
KW - Zeaxanthin
KW - Macular pigment optical density
KW - Intestinal resection
U2 - 10.1017/jns.2017.71
DO - 10.1017/jns.2017.71
M3 - Letter
C2 - 29430299
VL - 7
JO - Journal of Nutritional Science
JF - Journal of Nutritional Science
SN - 2048-6790
M1 - e8
ER -
ID: 189322199