Omega-3 fatty acids and risk of cardiovascular disease in Inuit: First prospective cohort study
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Omega-3 fatty acids and risk of cardiovascular disease in Inuit : First prospective cohort study. / Senftleber, Ninna Karsbæk; Albrechtsen, Anders; Lauritzen, Lotte; Larsen, Christina Lytken; Bjerregaard, Peter; Diaz, Lars J.; Rønn, Pernille F; Jørgensen, Marit Eika.
In: Atherosclerosis, Vol. 312, 2020, p. 28-34.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Omega-3 fatty acids and risk of cardiovascular disease in Inuit
T2 - First prospective cohort study
AU - Senftleber, Ninna Karsbæk
AU - Albrechtsen, Anders
AU - Lauritzen, Lotte
AU - Larsen, Christina Lytken
AU - Bjerregaard, Peter
AU - Diaz, Lars J.
AU - Rønn, Pernille F
AU - Jørgensen, Marit Eika
N1 - Copyright © 2020 Elsevier B.V. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Background and aims: No prospective study have ever assessed if marine n-3 polyunsaturated fatty acids protect Inuit against cardiovascular disease as claimed. It is highly relevant as cardiovascular disease (CVD) incidence rates are rising concurrent with a westernization of diet. We aimed to assess the association between blood cell membrane phospholipid content of eicosapentaenoic acid and docosahexaenoic acid (EPA + DHA) on CVD risk in Inuit.Methods: We used data from a cohort of adult Greenlanders with follow-up in national registers. The main outcome was fatal and non-fatal CVD incidence among participants without previous CVD. The continuous effect of EPA + DHA was calculated as incidence rate ratios (IRRs) using Poisson regression with age as time scale, adjusting for age, sex, genetic admixture, lifestyle and dietary risk factors.Results: Out of 3095 eligible participants, 2924 were included. During a median follow-up of 9.7 years, 216 had their first CVD event (8.3 events/1000 person years). No association between EPA + DHA and CVD risk was seen, with IRR = 0.99 per percentage point EPA + DHA increase (95% CI: 0.95-1.03, p = 0.59). No association was seen with risk of ischemic heart disease (IHD) (IRR = 1.03, 95% CI: 0.97-1.09) and stroke (IRR = 0.98, 95% CI: 0.93-1.03) as separate outcomes or for intake of EPA and DHA.Conclusions: We can exclude that the CVD risk reduction is larger than 21% for individuals at the 75% EPA + DHA percentile compared to the 25% percentile. We need a larger sample size and/or longer follow-up to detect smaller effects and associations with IHD and/or stroke.
AB - Background and aims: No prospective study have ever assessed if marine n-3 polyunsaturated fatty acids protect Inuit against cardiovascular disease as claimed. It is highly relevant as cardiovascular disease (CVD) incidence rates are rising concurrent with a westernization of diet. We aimed to assess the association between blood cell membrane phospholipid content of eicosapentaenoic acid and docosahexaenoic acid (EPA + DHA) on CVD risk in Inuit.Methods: We used data from a cohort of adult Greenlanders with follow-up in national registers. The main outcome was fatal and non-fatal CVD incidence among participants without previous CVD. The continuous effect of EPA + DHA was calculated as incidence rate ratios (IRRs) using Poisson regression with age as time scale, adjusting for age, sex, genetic admixture, lifestyle and dietary risk factors.Results: Out of 3095 eligible participants, 2924 were included. During a median follow-up of 9.7 years, 216 had their first CVD event (8.3 events/1000 person years). No association between EPA + DHA and CVD risk was seen, with IRR = 0.99 per percentage point EPA + DHA increase (95% CI: 0.95-1.03, p = 0.59). No association was seen with risk of ischemic heart disease (IHD) (IRR = 1.03, 95% CI: 0.97-1.09) and stroke (IRR = 0.98, 95% CI: 0.93-1.03) as separate outcomes or for intake of EPA and DHA.Conclusions: We can exclude that the CVD risk reduction is larger than 21% for individuals at the 75% EPA + DHA percentile compared to the 25% percentile. We need a larger sample size and/or longer follow-up to detect smaller effects and associations with IHD and/or stroke.
KW - Faculty of Science
KW - Cardiovascular disease
KW - Ischemic heart disease
KW - Stroke
KW - n-3
KW - Polyunsaturated fatty acid
KW - Fish
KW - Inuit
KW - Greenland
KW - Circumpolar
KW - Arctic
KW - Epidemiology
U2 - 10.1016/j.atherosclerosis.2020.08.032
DO - 10.1016/j.atherosclerosis.2020.08.032
M3 - Journal article
C2 - 32949835
VL - 312
SP - 28
EP - 34
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
ER -
ID: 249058984