Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper
Research output: Contribution to journal › Journal article › Research › peer-review
Young mink kits (n = 8)were vaccinated withDNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodieswere induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres. The VN antibody titres remained high for more than 4 months and the mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN- producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV.
Original language | English |
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Journal | Vaccine |
Volume | 27 |
Issue number | 38 |
Pages (from-to) | 5178–5183 |
Number of pages | 6 |
ISSN | 0264-410X |
DOIs | |
Publication status | Published - 2009 |
- Former Faculty of Life Sciences
Research areas
ID: 13458253