Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents. / Vitola, Bernadette E; Deivanayagam, Sheela; Stein, Richard I; Mohammed, Balsamanirina S; Magkos, Faidon; Kirk, Erik P; Klein, Samuel.

In: Obesity, Vol. 17, No. 9, 2009, p. 1744-1748.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vitola, BE, Deivanayagam, S, Stein, RI, Mohammed, BS, Magkos, F, Kirk, EP & Klein, S 2009, 'Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents', Obesity, vol. 17, no. 9, pp. 1744-1748. https://doi.org/10.1038/oby.2009.171

APA

Vitola, B. E., Deivanayagam, S., Stein, R. I., Mohammed, B. S., Magkos, F., Kirk, E. P., & Klein, S. (2009). Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents. Obesity, 17(9), 1744-1748. https://doi.org/10.1038/oby.2009.171

Vancouver

Vitola BE, Deivanayagam S, Stein RI, Mohammed BS, Magkos F, Kirk EP et al. Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents. Obesity. 2009;17(9):1744-1748. https://doi.org/10.1038/oby.2009.171

Author

Vitola, Bernadette E ; Deivanayagam, Sheela ; Stein, Richard I ; Mohammed, Balsamanirina S ; Magkos, Faidon ; Kirk, Erik P ; Klein, Samuel. / Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents. In: Obesity. 2009 ; Vol. 17, No. 9. pp. 1744-1748.

Bibtex

@article{ea40371b61f446d991dd10cd75833f2f,
title = "Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents",
abstract = "Obesity in adolescents is associated with metabolic risk factors for type 2 diabetes, particularly insulin resistance and excessive accumulation of intrahepatic triglyceride (IHTG). The purpose of this study was to evaluate the effect of moderate weight loss on IHTG content and insulin sensitivity in obese adolescents who had normal oral glucose tolerance. Insulin sensitivity, assessed by using the hyperinsulinemic-euglycemic clamp technique in conjunction with stable isotopically labeled tracer infusion, and IHTG content, assessed by using magnetic resonance spectroscopy, were evaluated in eight obese adolescents (BMI >or=95th percentile for age and sex; age 15.3 +/- 0.6 years) before and after moderate diet-induced weight loss (8.2 +/- 2.0% of initial body weight). Weight loss caused a 61.6 +/- 8.5% decrease in IHTG content (P = 0.01), and improved both hepatic (56 +/- 18% increase in hepatic insulin sensitivity index, P = 0.01) and skeletal muscle (97 +/- 45% increase in insulin-mediated glucose disposal, P = 0.01) insulin sensitivity. Moderate diet-induced weight loss decreases IHTG content and improves insulin sensitivity in the liver and skeletal muscle in obese adolescents who have normal glucose tolerance. These results support the benefits of weight loss therapy in obese adolescents who do not have evidence of obesity-related metabolic complications during a standard medical evaluation.",
keywords = "Adolescent, Adolescent Behavior, Behavior Therapy, Blood Glucose/metabolism, Energy Intake, Exercise, Female, Glucose Clamp Technique, Glucose Tolerance Test, Humans, Insulin/metabolism, Insulin Resistance, Kinetics, Liver/metabolism, Magnetic Resonance Spectroscopy, Male, Muscle, Skeletal/metabolism, Obesity/metabolism, Risk Reduction Behavior, Treatment Outcome, Triglycerides/metabolism, Weight Loss",
author = "Vitola, {Bernadette E} and Sheela Deivanayagam and Stein, {Richard I} and Mohammed, {Balsamanirina S} and Faidon Magkos and Kirk, {Erik P} and Samuel Klein",
note = "(Ekstern)",
year = "2009",
doi = "10.1038/oby.2009.171",
language = "English",
volume = "17",
pages = "1744--1748",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents

AU - Vitola, Bernadette E

AU - Deivanayagam, Sheela

AU - Stein, Richard I

AU - Mohammed, Balsamanirina S

AU - Magkos, Faidon

AU - Kirk, Erik P

AU - Klein, Samuel

N1 - (Ekstern)

PY - 2009

Y1 - 2009

N2 - Obesity in adolescents is associated with metabolic risk factors for type 2 diabetes, particularly insulin resistance and excessive accumulation of intrahepatic triglyceride (IHTG). The purpose of this study was to evaluate the effect of moderate weight loss on IHTG content and insulin sensitivity in obese adolescents who had normal oral glucose tolerance. Insulin sensitivity, assessed by using the hyperinsulinemic-euglycemic clamp technique in conjunction with stable isotopically labeled tracer infusion, and IHTG content, assessed by using magnetic resonance spectroscopy, were evaluated in eight obese adolescents (BMI >or=95th percentile for age and sex; age 15.3 +/- 0.6 years) before and after moderate diet-induced weight loss (8.2 +/- 2.0% of initial body weight). Weight loss caused a 61.6 +/- 8.5% decrease in IHTG content (P = 0.01), and improved both hepatic (56 +/- 18% increase in hepatic insulin sensitivity index, P = 0.01) and skeletal muscle (97 +/- 45% increase in insulin-mediated glucose disposal, P = 0.01) insulin sensitivity. Moderate diet-induced weight loss decreases IHTG content and improves insulin sensitivity in the liver and skeletal muscle in obese adolescents who have normal glucose tolerance. These results support the benefits of weight loss therapy in obese adolescents who do not have evidence of obesity-related metabolic complications during a standard medical evaluation.

AB - Obesity in adolescents is associated with metabolic risk factors for type 2 diabetes, particularly insulin resistance and excessive accumulation of intrahepatic triglyceride (IHTG). The purpose of this study was to evaluate the effect of moderate weight loss on IHTG content and insulin sensitivity in obese adolescents who had normal oral glucose tolerance. Insulin sensitivity, assessed by using the hyperinsulinemic-euglycemic clamp technique in conjunction with stable isotopically labeled tracer infusion, and IHTG content, assessed by using magnetic resonance spectroscopy, were evaluated in eight obese adolescents (BMI >or=95th percentile for age and sex; age 15.3 +/- 0.6 years) before and after moderate diet-induced weight loss (8.2 +/- 2.0% of initial body weight). Weight loss caused a 61.6 +/- 8.5% decrease in IHTG content (P = 0.01), and improved both hepatic (56 +/- 18% increase in hepatic insulin sensitivity index, P = 0.01) and skeletal muscle (97 +/- 45% increase in insulin-mediated glucose disposal, P = 0.01) insulin sensitivity. Moderate diet-induced weight loss decreases IHTG content and improves insulin sensitivity in the liver and skeletal muscle in obese adolescents who have normal glucose tolerance. These results support the benefits of weight loss therapy in obese adolescents who do not have evidence of obesity-related metabolic complications during a standard medical evaluation.

KW - Adolescent

KW - Adolescent Behavior

KW - Behavior Therapy

KW - Blood Glucose/metabolism

KW - Energy Intake

KW - Exercise

KW - Female

KW - Glucose Clamp Technique

KW - Glucose Tolerance Test

KW - Humans

KW - Insulin/metabolism

KW - Insulin Resistance

KW - Kinetics

KW - Liver/metabolism

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Muscle, Skeletal/metabolism

KW - Obesity/metabolism

KW - Risk Reduction Behavior

KW - Treatment Outcome

KW - Triglycerides/metabolism

KW - Weight Loss

U2 - 10.1038/oby.2009.171

DO - 10.1038/oby.2009.171

M3 - Journal article

C2 - 19498349

VL - 17

SP - 1744

EP - 1748

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 9

ER -

ID: 290672286