Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients
Research output: Contribution to journal › Journal article › Research › peer-review
Context: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM.
Objective: We investigated the association between PTDM and single-nucleotide polymorphisms of ADIPOQ and ADIPOR1 in a cohort of renal allograft recipients.
Design, setting, and participants: Five hundred seventy-five patients (367 men and 208 women) who received kidney transplants between 1989 and 2007, without a history of diabetes and with a pretransplant fasting glucose concentration less than 5.5 mmol/liter. Patients were followed up for a median 10 yr. Genotypes included single-nucleotide polymorphisms of the following: ADIPOQ rs266729, rs822395, rs822396, rs2241766, and rs1501299 and ADIPOR1 rs2232853, rs12733285, and rs1342387.
Results: TT-homozygotes in ADIPOQ rs1501299 [hazard ratio (HR) = 1.70, P = 0.032] had greater risk of PTDM after adjusting for age, sex, amount of weight gain, and type of immunosuppressant. There was a significant interaction between sex and ADIPOQ rs1501299 genotype (P = 0.037). In men, but not in women, TT-homozygotes in ADIPOQ rs1501299 were more likely to develop PTDM than the wild GG-homozygotes (HR = 2.50, P = 0.002), whereas GT-heterozygotes had nonsignificantly elevated risk (HR = 1.41, P = 0.128).
Conclusion: Genetic variation in ADIPOQ rs1501299 is associated with PTDM in a sex-specific manner.
Original language | English |
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Journal | Journal of Clinical Endocrinology and Metabolism |
Volume | 97 |
Issue number | 1 |
Pages (from-to) | E129-E135 |
Number of pages | 7 |
ISSN | 0021-972X |
DOIs | |
Publication status | Published - 2012 |
Externally published | Yes |
- Adiponectin/genetics, Adult, Diabetes Mellitus/etiology, Female, Follow-Up Studies, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Kidney Transplantation/adverse effects, Male, Middle Aged, Polymorphism, Single Nucleotide/physiology, Receptors, Adiponectin/genetics, Sex Factors, Transplantation, Homologous
Research areas
ID: 290036519