Metabolic actions of insulin in men and women
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Metabolic actions of insulin in men and women. / Magkos, Faidon; Wang, Xuewen; Mittendorfer, Bettina.
In: Nutrition, Vol. 26, No. 7-8, 2010, p. 686-693.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Metabolic actions of insulin in men and women
AU - Magkos, Faidon
AU - Wang, Xuewen
AU - Mittendorfer, Bettina
N1 - 2010 Elsevier Inc. All rights reserved.
PY - 2010
Y1 - 2010
N2 - Insulin is an important regulator of glucose, lipid, and protein metabolism. It suppresses hepatic glucose and triglyceride production, inhibits adipose tissue lipolysis and whole-body and muscle proteolysis, and stimulates glucose uptake in muscle. In this review we discuss what is currently known about the control of substrate metabolism by insulin in men and women. The data available so far indicate that women are more sensitive to insulin with regards to glucose metabolism (both in the liver and in muscle), whereas there are no differences between men and women in insulin action on lipolysis. Potential differences exist in the regulation of plasma triglyceride concentration and protein metabolism by insulin and in changes in insulin action in response to stimuli (e.g., weight loss and exercise) that are known to alter insulin sensitivity. However, these areas have not been studied comprehensively enough to draw firm conclusions.
AB - Insulin is an important regulator of glucose, lipid, and protein metabolism. It suppresses hepatic glucose and triglyceride production, inhibits adipose tissue lipolysis and whole-body and muscle proteolysis, and stimulates glucose uptake in muscle. In this review we discuss what is currently known about the control of substrate metabolism by insulin in men and women. The data available so far indicate that women are more sensitive to insulin with regards to glucose metabolism (both in the liver and in muscle), whereas there are no differences between men and women in insulin action on lipolysis. Potential differences exist in the regulation of plasma triglyceride concentration and protein metabolism by insulin and in changes in insulin action in response to stimuli (e.g., weight loss and exercise) that are known to alter insulin sensitivity. However, these areas have not been studied comprehensively enough to draw firm conclusions.
KW - Exercise/physiology
KW - Female
KW - Glucose/metabolism
KW - Humans
KW - Insulin/metabolism
KW - Insulin Resistance/physiology
KW - Male
KW - Proteins/metabolism
KW - Sex Factors
KW - Triglycerides/blood
KW - Weight Loss/physiology
U2 - 10.1016/j.nut.2009.10.013
DO - 10.1016/j.nut.2009.10.013
M3 - Review
C2 - 20392600
VL - 26
SP - 686
EP - 693
JO - Nutrition
JF - Nutrition
SN - 0899-9007
IS - 7-8
ER -
ID: 290668180