Insulin sensitivity is not associated with palmitoleate availability in obese humans
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Insulin sensitivity is not associated with palmitoleate availability in obese humans. / Fabbrini, Elisa; Magkos, Faidon; Su, Xiong; Abumrad, Nada A; Nejedly, Nicole; Coughlin, Carrie C; Okunade, Adewole L; Patterson, Bruce W; Klein, Samuel.
In: Journal of Lipid Research, Vol. 52, No. 4, 2011, p. 808-812.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Insulin sensitivity is not associated with palmitoleate availability in obese humans
AU - Fabbrini, Elisa
AU - Magkos, Faidon
AU - Su, Xiong
AU - Abumrad, Nada A
AU - Nejedly, Nicole
AU - Coughlin, Carrie C
AU - Okunade, Adewole L
AU - Patterson, Bruce W
AU - Klein, Samuel
N1 - (Ekstern)
PY - 2011
Y1 - 2011
N2 - We evaluated whether insulin resistance in obese people is associated with decreased plasma palmitoleate availability. Palmitoleate content (percentage and absolute concentrations) in FFA and VLDL was measured in obese subjects who were either insulin resistant (IR) or insulin sensitive (IS), based on assessment of multiorgan (skeletal muscle, liver, and adipose tissue) insulin sensitivity by using the hyperinsulinemic-euglycemic clamp procedure in conjunction with infusion of stable isotopically labeled tracers. Plasma palmitoleate concentration and the relative contribution of palmitoleate to total plasma FFA concentration in the IS group (0.018 ± 0.002 mmol/l and 4.4% ± 0.2%, respectively) were not significantly different than values in the IR group (0.023 ± 0.003 mmol/l and 4.4% ± 0.4%, respectively). Plasma VLDL-triglyceride palmitoleate concentration and the proportion of VLDL fatty acids as palmitoleate in the IS group (0.09 ± 0.02 mmol/l and 5.7 ± 0.3%, respectively) were also not significantly different than those in the IR group (0.16 ± 0.04 mmol/l and 5.0% ± 0.4%, respectively). These data demonstrate that decreased palmitoleate in plasma and in VLDL is not associated with insulin resistance in skeletal muscle, liver, or adipose tissue in obese people.
AB - We evaluated whether insulin resistance in obese people is associated with decreased plasma palmitoleate availability. Palmitoleate content (percentage and absolute concentrations) in FFA and VLDL was measured in obese subjects who were either insulin resistant (IR) or insulin sensitive (IS), based on assessment of multiorgan (skeletal muscle, liver, and adipose tissue) insulin sensitivity by using the hyperinsulinemic-euglycemic clamp procedure in conjunction with infusion of stable isotopically labeled tracers. Plasma palmitoleate concentration and the relative contribution of palmitoleate to total plasma FFA concentration in the IS group (0.018 ± 0.002 mmol/l and 4.4% ± 0.2%, respectively) were not significantly different than values in the IR group (0.023 ± 0.003 mmol/l and 4.4% ± 0.4%, respectively). Plasma VLDL-triglyceride palmitoleate concentration and the proportion of VLDL fatty acids as palmitoleate in the IS group (0.09 ± 0.02 mmol/l and 5.7 ± 0.3%, respectively) were also not significantly different than those in the IR group (0.16 ± 0.04 mmol/l and 5.0% ± 0.4%, respectively). These data demonstrate that decreased palmitoleate in plasma and in VLDL is not associated with insulin resistance in skeletal muscle, liver, or adipose tissue in obese people.
KW - Adipose Tissue/metabolism
KW - Adult
KW - Fatty Acids, Monounsaturated/blood
KW - Fatty Acids, Nonesterified/blood
KW - Female
KW - Glucose Clamp Technique
KW - Humans
KW - Insulin Resistance/physiology
KW - Lipoproteins, VLDL/blood
KW - Liver/metabolism
KW - Male
KW - Muscle, Skeletal/metabolism
KW - Obesity/blood
KW - Stearoyl-CoA Desaturase/genetics
U2 - 10.1194/jlr.M013599
DO - 10.1194/jlr.M013599
M3 - Journal article
C2 - 21266364
VL - 52
SP - 808
EP - 812
JO - Journal of Lipid Research
JF - Journal of Lipid Research
SN - 0022-2275
IS - 4
ER -
ID: 290519802