Estimated liver weight is directly related to hepatic very low-density lipoprotein-triglyceride secretion rate in men

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Estimated liver weight is directly related to hepatic very low-density lipoprotein-triglyceride secretion rate in men. / Tsekouras, Y E; Magkos, Faidon; Kavouras, S A; Panagiotakos, D B; Sidossis, Labros S.

In: European Journal of Clinical Investigation, Vol. 38, No. 9, 2008, p. 656-662.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tsekouras, YE, Magkos, F, Kavouras, SA, Panagiotakos, DB & Sidossis, LS 2008, 'Estimated liver weight is directly related to hepatic very low-density lipoprotein-triglyceride secretion rate in men', European Journal of Clinical Investigation, vol. 38, no. 9, pp. 656-662. https://doi.org/10.1111/j.1365-2362.2008.01999.x

APA

Tsekouras, Y. E., Magkos, F., Kavouras, S. A., Panagiotakos, D. B., & Sidossis, L. S. (2008). Estimated liver weight is directly related to hepatic very low-density lipoprotein-triglyceride secretion rate in men. European Journal of Clinical Investigation, 38(9), 656-662. https://doi.org/10.1111/j.1365-2362.2008.01999.x

Vancouver

Tsekouras YE, Magkos F, Kavouras SA, Panagiotakos DB, Sidossis LS. Estimated liver weight is directly related to hepatic very low-density lipoprotein-triglyceride secretion rate in men. European Journal of Clinical Investigation. 2008;38(9):656-662. https://doi.org/10.1111/j.1365-2362.2008.01999.x

Author

Tsekouras, Y E ; Magkos, Faidon ; Kavouras, S A ; Panagiotakos, D B ; Sidossis, Labros S. / Estimated liver weight is directly related to hepatic very low-density lipoprotein-triglyceride secretion rate in men. In: European Journal of Clinical Investigation. 2008 ; Vol. 38, No. 9. pp. 656-662.

Bibtex

@article{0ad10aa32b8f458daa67a3337c7fb147,
title = "Estimated liver weight is directly related to hepatic very low-density lipoprotein-triglyceride secretion rate in men",
abstract = "Background: Animal studies suggest that liver weight is directly related to hepatic very low-density lipoprotein-triglyceride (VLDL-TG) secretion, independently of body size. This relationship has never been examined in humans.Materials and methods: We measured VLDL-TG secretion rate by using stable isotope-labelled tracers in 21 healthy, non-obese men (age: 25 +/- 3 years; body mass index: 24.8 +/- 1.6 kg m-2), and evaluated the relationship between VLDL-TG secretion and indices of total and regional adiposity (body mass index, total body fat, trunk fat), metabolic parameters (free fatty acid, glucose, and insulin concentrations, homeostasis model assessment index of insulin resistance, resting energy expenditure), and estimated liver weight.Results: Correlation analysis showed that estimated liver weight was positively associated with total VLDL-TG secretion rate (r = 0.722, P < 0.001), VLDL-TG secretion rate per liter of plasma (r = 0.562, P = 0.008), VLDL-TG secretion rate per kilogram of body weight (r = 0.555, P = 0.009), and VLDL-TG secretion rate per kilogram of liver weight (r = 0.620, P = 0.003). In multiple regression analysis, estimated liver weight was the only significant predictor of VLDL-TG secretion rate regardless of units of expression, explaining 31-52% of total variance; none of the metabolic parameters and indices of body fatness entered the regression models.Conclusions: We conclude that estimated liver weight is directly related to hepatic VLDL-TG secretion rate in healthy non-obese men; this relationship is likely not mediated by interindividual variation in body size.",
keywords = "Adult, Blood Glucose/metabolism, Body Composition/physiology, Body Mass Index, Energy Metabolism/physiology, Fatty Acids, Nonesterified/metabolism, Gas Chromatography-Mass Spectrometry, Humans, Insulin Resistance/physiology, Lipoproteins, VLDL/metabolism, Liver/anatomy & histology, Male, Organ Size/physiology, Triglycerides/metabolism",
author = "Tsekouras, {Y E} and Faidon Magkos and Kavouras, {S A} and Panagiotakos, {D B} and Sidossis, {Labros S}",
note = "(Ekstern)",
year = "2008",
doi = "10.1111/j.1365-2362.2008.01999.x",
language = "English",
volume = "38",
pages = "656--662",
journal = "European Journal of Clinical Investigation, Supplement",
issn = "0960-135X",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Estimated liver weight is directly related to hepatic very low-density lipoprotein-triglyceride secretion rate in men

AU - Tsekouras, Y E

AU - Magkos, Faidon

AU - Kavouras, S A

AU - Panagiotakos, D B

AU - Sidossis, Labros S

N1 - (Ekstern)

PY - 2008

Y1 - 2008

N2 - Background: Animal studies suggest that liver weight is directly related to hepatic very low-density lipoprotein-triglyceride (VLDL-TG) secretion, independently of body size. This relationship has never been examined in humans.Materials and methods: We measured VLDL-TG secretion rate by using stable isotope-labelled tracers in 21 healthy, non-obese men (age: 25 +/- 3 years; body mass index: 24.8 +/- 1.6 kg m-2), and evaluated the relationship between VLDL-TG secretion and indices of total and regional adiposity (body mass index, total body fat, trunk fat), metabolic parameters (free fatty acid, glucose, and insulin concentrations, homeostasis model assessment index of insulin resistance, resting energy expenditure), and estimated liver weight.Results: Correlation analysis showed that estimated liver weight was positively associated with total VLDL-TG secretion rate (r = 0.722, P < 0.001), VLDL-TG secretion rate per liter of plasma (r = 0.562, P = 0.008), VLDL-TG secretion rate per kilogram of body weight (r = 0.555, P = 0.009), and VLDL-TG secretion rate per kilogram of liver weight (r = 0.620, P = 0.003). In multiple regression analysis, estimated liver weight was the only significant predictor of VLDL-TG secretion rate regardless of units of expression, explaining 31-52% of total variance; none of the metabolic parameters and indices of body fatness entered the regression models.Conclusions: We conclude that estimated liver weight is directly related to hepatic VLDL-TG secretion rate in healthy non-obese men; this relationship is likely not mediated by interindividual variation in body size.

AB - Background: Animal studies suggest that liver weight is directly related to hepatic very low-density lipoprotein-triglyceride (VLDL-TG) secretion, independently of body size. This relationship has never been examined in humans.Materials and methods: We measured VLDL-TG secretion rate by using stable isotope-labelled tracers in 21 healthy, non-obese men (age: 25 +/- 3 years; body mass index: 24.8 +/- 1.6 kg m-2), and evaluated the relationship between VLDL-TG secretion and indices of total and regional adiposity (body mass index, total body fat, trunk fat), metabolic parameters (free fatty acid, glucose, and insulin concentrations, homeostasis model assessment index of insulin resistance, resting energy expenditure), and estimated liver weight.Results: Correlation analysis showed that estimated liver weight was positively associated with total VLDL-TG secretion rate (r = 0.722, P < 0.001), VLDL-TG secretion rate per liter of plasma (r = 0.562, P = 0.008), VLDL-TG secretion rate per kilogram of body weight (r = 0.555, P = 0.009), and VLDL-TG secretion rate per kilogram of liver weight (r = 0.620, P = 0.003). In multiple regression analysis, estimated liver weight was the only significant predictor of VLDL-TG secretion rate regardless of units of expression, explaining 31-52% of total variance; none of the metabolic parameters and indices of body fatness entered the regression models.Conclusions: We conclude that estimated liver weight is directly related to hepatic VLDL-TG secretion rate in healthy non-obese men; this relationship is likely not mediated by interindividual variation in body size.

KW - Adult

KW - Blood Glucose/metabolism

KW - Body Composition/physiology

KW - Body Mass Index

KW - Energy Metabolism/physiology

KW - Fatty Acids, Nonesterified/metabolism

KW - Gas Chromatography-Mass Spectrometry

KW - Humans

KW - Insulin Resistance/physiology

KW - Lipoproteins, VLDL/metabolism

KW - Liver/anatomy & histology

KW - Male

KW - Organ Size/physiology

KW - Triglycerides/metabolism

U2 - 10.1111/j.1365-2362.2008.01999.x

DO - 10.1111/j.1365-2362.2008.01999.x

M3 - Journal article

C2 - 18837742

VL - 38

SP - 656

EP - 662

JO - European Journal of Clinical Investigation, Supplement

JF - European Journal of Clinical Investigation, Supplement

SN - 0960-135X

IS - 9

ER -

ID: 290674041