Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition
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Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition. / Yaméogo, Charles W; Cichon, Bernardette; Fabiansen, Christian; Rytter, Maren Johanne Heilskov; Faurholt-Jepsen, Daniel; Stark, K D; Briend, André; Shepherd, S; Traoré, A S; Christensen, Vibeke Bak; Michaelsen, Kim F.; Friis, Henrik; Lauritzen, Lotte.
In: Nutrition Journal, Vol. 16, 44, 2017.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition
AU - Yaméogo, Charles W
AU - Cichon, Bernardette
AU - Fabiansen, Christian
AU - Rytter, Maren Johanne Heilskov
AU - Faurholt-Jepsen, Daniel
AU - Stark, K D
AU - Briend, André
AU - Shepherd, S
AU - Traoré, A S
AU - Christensen, Vibeke Bak
AU - Michaelsen, Kim F.
AU - Friis, Henrik
AU - Lauritzen, Lotte
N1 - CURIS 2017 NEXS 197
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Severe acute malnutrition (SAM) has been associated with low polyunsaturated fatty acid (PUFA) status. However, investigations regarding PUFA status and correlates in children with moderate acute malnutrition (MAM) from low-income countries are scarce. The aim of this study was to describe whole-blood PUFA levels in children with moderate acute malnutrition (MAM) and to identify correlates of PUFAs.METHODS: We conducted a cross-sectional study using baseline data from a prospective nutritional intervention trial among 1609 children with MAM aged 6-23 months in Burkina Faso,West Africa. Whole-blood PUFAs were measured by gas chromatography and expressed as percent of total whole-blood fatty acids (FA%). Potential correlates of PUFAs including infection, inflammation, hemoglobin, anthropometry (difference between children diagnosed as having MAM based on low mid-upper-arm-circumference (MUAC) only, low MUAC and weight-for-height z-score (WHZ), or low WHZ only) and diet were assessed by linear regression adjusted for age and sex.RESULTS: Children with MAM had low concentrations of whole-blood PUFAs, particularly n-3 PUFAs. Moreover, children diagnosed with MAM based only on low MUAC had 0.32 (95% confidence interval (CI), 0.14; 0.50) and 0.40 (95% CI, 0.16; 0.63) FA% lower arachidonic acid (AA) than those recruited based on both low WHZ as well as low MUAC and those recruited with low WHZ only, respectively. Infection and inflammation were associated with low levels of all long-chain (LC)-PUFAs, while hemoglobin was positively associated with whole-blood LC-PUFAs.CONCLUSION: While PUFA deficiency was not a general problem, overall whole-blood PUFA concentrations, especially of n-3 PUFAs, were low. Infection, inflammation, hemoglobin, anthropometry and diet were correlates of PUFAs concentrations in children with MAM.TRIAL REGISTRATION: The trial is registered at http://www.isrctn.com ( ISRCTN42569496 ).
AB - BACKGROUND: Severe acute malnutrition (SAM) has been associated with low polyunsaturated fatty acid (PUFA) status. However, investigations regarding PUFA status and correlates in children with moderate acute malnutrition (MAM) from low-income countries are scarce. The aim of this study was to describe whole-blood PUFA levels in children with moderate acute malnutrition (MAM) and to identify correlates of PUFAs.METHODS: We conducted a cross-sectional study using baseline data from a prospective nutritional intervention trial among 1609 children with MAM aged 6-23 months in Burkina Faso,West Africa. Whole-blood PUFAs were measured by gas chromatography and expressed as percent of total whole-blood fatty acids (FA%). Potential correlates of PUFAs including infection, inflammation, hemoglobin, anthropometry (difference between children diagnosed as having MAM based on low mid-upper-arm-circumference (MUAC) only, low MUAC and weight-for-height z-score (WHZ), or low WHZ only) and diet were assessed by linear regression adjusted for age and sex.RESULTS: Children with MAM had low concentrations of whole-blood PUFAs, particularly n-3 PUFAs. Moreover, children diagnosed with MAM based only on low MUAC had 0.32 (95% confidence interval (CI), 0.14; 0.50) and 0.40 (95% CI, 0.16; 0.63) FA% lower arachidonic acid (AA) than those recruited based on both low WHZ as well as low MUAC and those recruited with low WHZ only, respectively. Infection and inflammation were associated with low levels of all long-chain (LC)-PUFAs, while hemoglobin was positively associated with whole-blood LC-PUFAs.CONCLUSION: While PUFA deficiency was not a general problem, overall whole-blood PUFA concentrations, especially of n-3 PUFAs, were low. Infection, inflammation, hemoglobin, anthropometry and diet were correlates of PUFAs concentrations in children with MAM.TRIAL REGISTRATION: The trial is registered at http://www.isrctn.com ( ISRCTN42569496 ).
KW - Essential fatty acids
KW - Undernourished children
KW - Diet
KW - Morbidity
U2 - 10.1186/s12937-017-0264-3
DO - 10.1186/s12937-017-0264-3
M3 - Journal article
C2 - 28705254
VL - 16
JO - Nutrition Journal
JF - Nutrition Journal
SN - 1475-2891
M1 - 44
ER -
ID: 181935803