Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans
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Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans. / Kang, Eun Seok; Magkos, Faidon; Sienkiewicz, Elizabeth; Mantzoros, Christos S.
In: European Journal of Endocrinology, Vol. 164, No. 6, 2011, p. 911-917.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans
AU - Kang, Eun Seok
AU - Magkos, Faidon
AU - Sienkiewicz, Elizabeth
AU - Mantzoros, Christos S
N1 - (Ekstern)
PY - 2011
Y1 - 2011
N2 - Objective: Animal and in vitro studies indicate that leptin alleviates starvation-induced reduction in circulating vaspin and stimulates the production of visfatin. We thus examined whether vaspin and visfatin are affected by short- and long-term energy deprivation and leptin administration in human subjects in vivo.Design and methods: We measured circulating levels of vaspin and visfatin i) before and after 72 h of starvation (leading to severe hypoleptinemia) with or without leptin administration in replacement doses in 13 normal-weight subjects, ii) before and after 72 h of starvation with leptin administration in pharmacological doses in 13 lean and obese subjects, iii) during chronic energy deficiency in eight women with hypothalamic amenorrhea on leptin replacement for 3 months, and iv) during chronic energy deficiency in 18 women with hypothalamic amenorrhea on leptin replacement or placebo for 3 months.Results: Acute starvation decreased serum leptin to 21% of baseline values, (P=0.002) but had no significant effect on vaspin and visfatin concentrations (P>0.05). Nor did normalization of leptin levels affect the concentrations of these two adipokines (P>0.9). Leptin replacement in women with hypothalamic amenorrhea did not significantly alter vaspin and visfatin concentrations, whether relative to baseline or placebo administration (P>0.25). Pharmacological doses of leptin did not affect circulating vaspin and visfatin concentrations (P>0.9).Conclusions: Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency leading to hypoleptinemia and are not regulated by leptin in human subjects, indicating that these adipocyte-secreted hormonal regulators of metabolism are independently regulated in humans.
AB - Objective: Animal and in vitro studies indicate that leptin alleviates starvation-induced reduction in circulating vaspin and stimulates the production of visfatin. We thus examined whether vaspin and visfatin are affected by short- and long-term energy deprivation and leptin administration in human subjects in vivo.Design and methods: We measured circulating levels of vaspin and visfatin i) before and after 72 h of starvation (leading to severe hypoleptinemia) with or without leptin administration in replacement doses in 13 normal-weight subjects, ii) before and after 72 h of starvation with leptin administration in pharmacological doses in 13 lean and obese subjects, iii) during chronic energy deficiency in eight women with hypothalamic amenorrhea on leptin replacement for 3 months, and iv) during chronic energy deficiency in 18 women with hypothalamic amenorrhea on leptin replacement or placebo for 3 months.Results: Acute starvation decreased serum leptin to 21% of baseline values, (P=0.002) but had no significant effect on vaspin and visfatin concentrations (P>0.05). Nor did normalization of leptin levels affect the concentrations of these two adipokines (P>0.9). Leptin replacement in women with hypothalamic amenorrhea did not significantly alter vaspin and visfatin concentrations, whether relative to baseline or placebo administration (P>0.25). Pharmacological doses of leptin did not affect circulating vaspin and visfatin concentrations (P>0.9).Conclusions: Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency leading to hypoleptinemia and are not regulated by leptin in human subjects, indicating that these adipocyte-secreted hormonal regulators of metabolism are independently regulated in humans.
KW - Adult
KW - Amenorrhea/blood
KW - Double-Blind Method
KW - Energy Intake/physiology
KW - Enzyme-Linked Immunosorbent Assay
KW - Exercise/physiology
KW - Fasting/physiology
KW - Female
KW - Hormone Replacement Therapy
KW - Humans
KW - Hypothalamic Diseases/blood
KW - Leptin/blood
KW - Male
KW - Nicotinamide Phosphoribosyltransferase/blood
KW - Serpins/blood
KW - Young Adult
U2 - 10.1530/EJE-11-0052
DO - 10.1530/EJE-11-0052
M3 - Journal article
C2 - 21422197
VL - 164
SP - 911
EP - 917
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 6
ER -
ID: 290459156