Asian females without diabetes are protected from obesity-related dysregulation of glucose metabolism compared with males
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Asian females without diabetes are protected from obesity-related dysregulation of glucose metabolism compared with males. / Lee, Michelle H; Febriana, Eveline; Lim, Maybritte; Baig, Sonia; Halter, Jeffrey B; Magkos, Faidon; Toh, Sue-Anne.
In: Obesity, Vol. 31, No. 9, 2023, p. 2304-2314.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Asian females without diabetes are protected from obesity-related dysregulation of glucose metabolism compared with males
AU - Lee, Michelle H
AU - Febriana, Eveline
AU - Lim, Maybritte
AU - Baig, Sonia
AU - Halter, Jeffrey B
AU - Magkos, Faidon
AU - Toh, Sue-Anne
N1 - © 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
PY - 2023
Y1 - 2023
N2 - Objective: The impact of obesity on the risk for type 2 diabetes differs between males and females; however, the underlying reasons are unclear. This study aimed to investigate the effect of sex on obesity-driven changes in the mechanisms regulating glucose metabolism (insulin sensitivity and secretion) among Asian individuals without diabetes in Singapore.Methods: The study assessed glucose tolerance using oral glucose tolerance test, insulin-mediated glucose uptake using hyperinsulinemic-euglycemic clamp, acute insulin response using an intravenous glucose challenge, and insulin secretion rates in the fasting state and in response to glucose ingestion using mathematical modeling in 727 males and 952 females who had normal body weight (n = 602, BMI < 23 kg/m2), overweight (n = 662, 23 ≤ BMI < 27.5), or obesity (n = 415, BMI ≥ 27.5). Results: There were no sex differences among lean individuals. Obesity gradually worsened metabolic function, and the progressive adverse effects of obesity on insulin action and secretion were more pronounced in males than females, such that among participants with obesity, females had greater insulin sensitivity, lower insulin secretion, and lower fasting insulin concentration than males. The increase in waist to hip ratio with increasing BMI was more pronounced in males than females.Conclusions: The female sex exerts a protective effect on obesity-driven dysregulation of glucose metabolism in Asian individuals without diabetes.
AB - Objective: The impact of obesity on the risk for type 2 diabetes differs between males and females; however, the underlying reasons are unclear. This study aimed to investigate the effect of sex on obesity-driven changes in the mechanisms regulating glucose metabolism (insulin sensitivity and secretion) among Asian individuals without diabetes in Singapore.Methods: The study assessed glucose tolerance using oral glucose tolerance test, insulin-mediated glucose uptake using hyperinsulinemic-euglycemic clamp, acute insulin response using an intravenous glucose challenge, and insulin secretion rates in the fasting state and in response to glucose ingestion using mathematical modeling in 727 males and 952 females who had normal body weight (n = 602, BMI < 23 kg/m2), overweight (n = 662, 23 ≤ BMI < 27.5), or obesity (n = 415, BMI ≥ 27.5). Results: There were no sex differences among lean individuals. Obesity gradually worsened metabolic function, and the progressive adverse effects of obesity on insulin action and secretion were more pronounced in males than females, such that among participants with obesity, females had greater insulin sensitivity, lower insulin secretion, and lower fasting insulin concentration than males. The increase in waist to hip ratio with increasing BMI was more pronounced in males than females.Conclusions: The female sex exerts a protective effect on obesity-driven dysregulation of glucose metabolism in Asian individuals without diabetes.
U2 - 10.1002/oby.23833
DO - 10.1002/oby.23833
M3 - Journal article
C2 - 37534562
VL - 31
SP - 2304
EP - 2314
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 9
ER -
ID: 361546288