Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss. / Su, Xiong; Magkos, Faidon; Zhou, Dequan; Eagon, J Christopher; Fabbrini, Elisa; Okunade, Adewole L; Klein, Samuel.

In: Obesity, Vol. 23, No. 2, 2015, p. 329-334.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Su, X, Magkos, F, Zhou, D, Eagon, JC, Fabbrini, E, Okunade, AL & Klein, S 2015, 'Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss', Obesity, vol. 23, no. 2, pp. 329-334. https://doi.org/10.1002/oby.20923

APA

Su, X., Magkos, F., Zhou, D., Eagon, J. C., Fabbrini, E., Okunade, A. L., & Klein, S. (2015). Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss. Obesity, 23(2), 329-334. https://doi.org/10.1002/oby.20923

Vancouver

Su X, Magkos F, Zhou D, Eagon JC, Fabbrini E, Okunade AL et al. Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss. Obesity. 2015;23(2):329-334. https://doi.org/10.1002/oby.20923

Author

Su, Xiong ; Magkos, Faidon ; Zhou, Dequan ; Eagon, J Christopher ; Fabbrini, Elisa ; Okunade, Adewole L ; Klein, Samuel. / Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss. In: Obesity. 2015 ; Vol. 23, No. 2. pp. 329-334.

Bibtex

@article{fcc887bff518416eb492f53ced8460c5,
title = "Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss",
abstract = "Objectives: An increase in circulating branched-chain amino acids (BCAA) is associated with insulin resistance. Adipose tissue is a potentially important site for BCAA metabolism. It was evaluated whether monomethyl branched-chain fatty acids (mmBCFA) in adipose tissue, which are likely derived from BCAA catabolism, are associated with insulin sensitivity.Methods: Insulin-stimulated glucose disposal was determined by using the hyperinsulinemic-euglycemic clamp procedure with stable isotope glucose tracer infusion in nine lean and nine obese subjects, and in a separate group of nine obese subjects before and 1 year after Roux-en-Y gastric bypass (RYGB) surgery (38% weight loss). Adipose tissue mmBCFA content was measured in tissue biopsies taken in the basal state.Results: Total adipose tissue mmBCFA content was ∼30% lower in obese than lean subjects (P = 0.02) and increased by ∼65% after weight loss in the RYGB group (P = 0.01). Adipose tissue mmBCFA content correlated positively with skeletal muscle insulin sensitivity (R2 =35%, P = 0.01, n = 18).Conclusions: These results demonstrate a novel association between adipose tissue mmBCFA content and obesity-related insulin resistance. Additional studies are needed to determine whether the association between adipose tissue mmBCFA and muscle insulin sensitivity is causal or a simple association.",
keywords = "Adipose Tissue/metabolism, Adult, Cross-Sectional Studies, Fatty Acids/metabolism, Female, Gastric Bypass, Glucose Clamp Technique, Humans, Insulin/metabolism, Insulin Resistance/physiology, Longitudinal Studies, Male, Middle Aged, Obesity/metabolism, Weight Loss/physiology",
author = "Xiong Su and Faidon Magkos and Dequan Zhou and Eagon, {J Christopher} and Elisa Fabbrini and Okunade, {Adewole L} and Samuel Klein",
note = "{\textcopyright} 2014 The Obesity Society.",
year = "2015",
doi = "10.1002/oby.20923",
language = "English",
volume = "23",
pages = "329--334",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss

AU - Su, Xiong

AU - Magkos, Faidon

AU - Zhou, Dequan

AU - Eagon, J Christopher

AU - Fabbrini, Elisa

AU - Okunade, Adewole L

AU - Klein, Samuel

N1 - © 2014 The Obesity Society.

PY - 2015

Y1 - 2015

N2 - Objectives: An increase in circulating branched-chain amino acids (BCAA) is associated with insulin resistance. Adipose tissue is a potentially important site for BCAA metabolism. It was evaluated whether monomethyl branched-chain fatty acids (mmBCFA) in adipose tissue, which are likely derived from BCAA catabolism, are associated with insulin sensitivity.Methods: Insulin-stimulated glucose disposal was determined by using the hyperinsulinemic-euglycemic clamp procedure with stable isotope glucose tracer infusion in nine lean and nine obese subjects, and in a separate group of nine obese subjects before and 1 year after Roux-en-Y gastric bypass (RYGB) surgery (38% weight loss). Adipose tissue mmBCFA content was measured in tissue biopsies taken in the basal state.Results: Total adipose tissue mmBCFA content was ∼30% lower in obese than lean subjects (P = 0.02) and increased by ∼65% after weight loss in the RYGB group (P = 0.01). Adipose tissue mmBCFA content correlated positively with skeletal muscle insulin sensitivity (R2 =35%, P = 0.01, n = 18).Conclusions: These results demonstrate a novel association between adipose tissue mmBCFA content and obesity-related insulin resistance. Additional studies are needed to determine whether the association between adipose tissue mmBCFA and muscle insulin sensitivity is causal or a simple association.

AB - Objectives: An increase in circulating branched-chain amino acids (BCAA) is associated with insulin resistance. Adipose tissue is a potentially important site for BCAA metabolism. It was evaluated whether monomethyl branched-chain fatty acids (mmBCFA) in adipose tissue, which are likely derived from BCAA catabolism, are associated with insulin sensitivity.Methods: Insulin-stimulated glucose disposal was determined by using the hyperinsulinemic-euglycemic clamp procedure with stable isotope glucose tracer infusion in nine lean and nine obese subjects, and in a separate group of nine obese subjects before and 1 year after Roux-en-Y gastric bypass (RYGB) surgery (38% weight loss). Adipose tissue mmBCFA content was measured in tissue biopsies taken in the basal state.Results: Total adipose tissue mmBCFA content was ∼30% lower in obese than lean subjects (P = 0.02) and increased by ∼65% after weight loss in the RYGB group (P = 0.01). Adipose tissue mmBCFA content correlated positively with skeletal muscle insulin sensitivity (R2 =35%, P = 0.01, n = 18).Conclusions: These results demonstrate a novel association between adipose tissue mmBCFA content and obesity-related insulin resistance. Additional studies are needed to determine whether the association between adipose tissue mmBCFA and muscle insulin sensitivity is causal or a simple association.

KW - Adipose Tissue/metabolism

KW - Adult

KW - Cross-Sectional Studies

KW - Fatty Acids/metabolism

KW - Female

KW - Gastric Bypass

KW - Glucose Clamp Technique

KW - Humans

KW - Insulin/metabolism

KW - Insulin Resistance/physiology

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Obesity/metabolism

KW - Weight Loss/physiology

U2 - 10.1002/oby.20923

DO - 10.1002/oby.20923

M3 - Journal article

C2 - 25328153

VL - 23

SP - 329

EP - 334

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 2

ER -

ID: 289963282