Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls
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Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls. / Bruun, Signe; van Rossem, Lenie; Lauritzen, Lotte; Husby, Steffen; Neergaard Jacobsen, Lotte; Michaelsen, Kim F.; Boysen Sandberg, Maria; Stark, Ken D; Sørensen, Jan; Zachariassen, Gitte.
In: Nutrients, Vol. 11, No. 2, 235, 28.01.2019.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls
AU - Bruun, Signe
AU - van Rossem, Lenie
AU - Lauritzen, Lotte
AU - Husby, Steffen
AU - Neergaard Jacobsen, Lotte
AU - Michaelsen, Kim F.
AU - Boysen Sandberg, Maria
AU - Stark, Ken D
AU - Sørensen, Jan
AU - Zachariassen, Gitte
N1 - CURIS 2019 NEXS 037
PY - 2019/1/28
Y1 - 2019/1/28
N2 - Blood pressure (BP) and blood lipid profile (BLP) have been shown to track from childhood into adulthood, and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in breast milk have been suggested as mediators of the beneficial long-term effect of breastfeeding on BP and BLP. We aimed to investigate associations between n-3 LC-PUFA content in breast milk at 4 months postpartum and offspring BP and BLP in early life. BP and BLP were measured at 4, 18, and 36 months. Statistical analyses were sex-stratified and adjusted for gestational age, maternal pre-pregnancy body mass index (BMI), and maternal educational level. Based on 336 mother-child dyads, high n-3 LC-PUFA in breast milk was inversely associated with systolic and diastolic BP in boys at 4 months (β = -20.0 (95% CI = -33.4, -6.7), p = 0.004 and β = -10.2 (95% CI = -19.8, -0.5), p = 0.039, respectively); inversely associated with HDL cholesterol, and directly associated with triglyceride in girls at 4 months (β = -0.7 (95% CI = -1.1, -0.3), p = 0.001 and β = 3.1 (95% CI = 1.0, 5.2), p = 0.005, respectively). Associations observed at the later time points were non-significant. Furthermore, we observed sex-specific changes over time in both size and direction of the associations. Our results indicate that early intake of n-3 LC-PUFA can affect early development in cardiometabolic factors such as BP and BLP in a sex-specific manner. Follow-up and further investigation in later childhood is planned.
AB - Blood pressure (BP) and blood lipid profile (BLP) have been shown to track from childhood into adulthood, and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in breast milk have been suggested as mediators of the beneficial long-term effect of breastfeeding on BP and BLP. We aimed to investigate associations between n-3 LC-PUFA content in breast milk at 4 months postpartum and offspring BP and BLP in early life. BP and BLP were measured at 4, 18, and 36 months. Statistical analyses were sex-stratified and adjusted for gestational age, maternal pre-pregnancy body mass index (BMI), and maternal educational level. Based on 336 mother-child dyads, high n-3 LC-PUFA in breast milk was inversely associated with systolic and diastolic BP in boys at 4 months (β = -20.0 (95% CI = -33.4, -6.7), p = 0.004 and β = -10.2 (95% CI = -19.8, -0.5), p = 0.039, respectively); inversely associated with HDL cholesterol, and directly associated with triglyceride in girls at 4 months (β = -0.7 (95% CI = -1.1, -0.3), p = 0.001 and β = 3.1 (95% CI = 1.0, 5.2), p = 0.005, respectively). Associations observed at the later time points were non-significant. Furthermore, we observed sex-specific changes over time in both size and direction of the associations. Our results indicate that early intake of n-3 LC-PUFA can affect early development in cardiometabolic factors such as BP and BLP in a sex-specific manner. Follow-up and further investigation in later childhood is planned.
KW - Faculty of Science
KW - Cohort study
KW - Cardiovascular health
KW - Omega-3
KW - Fatty acids
KW - Human milk
KW - Milk composition
KW - Cholesterol
KW - Triglyceride
U2 - 10.3390/nu11020235
DO - 10.3390/nu11020235
M3 - Journal article
C2 - 30678226
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 2
M1 - 235
ER -
ID: 212905107