The influence of maternal obesity and breastfeeding on infant appetite- and growth-related hormone concentrations: The SKOT Cohort Studies
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The influence of maternal obesity and breastfeeding on infant appetite- and growth-related hormone concentrations : The SKOT Cohort Studies. / Larnkjær, Anni; Ong, Ken K; Carlsen, Emma M; Ejlerskov, Katrine Tschentscher; Mølgaard, Christian; Michaelsen, Kim F.
In: Hormone Research in Paediatrics, Vol. 90, No. 1, 2018, p. 28-38.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The influence of maternal obesity and breastfeeding on infant appetite- and growth-related hormone concentrations
T2 - The SKOT Cohort Studies
AU - Larnkjær, Anni
AU - Ong, Ken K
AU - Carlsen, Emma M
AU - Ejlerskov, Katrine Tschentscher
AU - Mølgaard, Christian
AU - Michaelsen, Kim F.
N1 - CURIS 2018 NEXS 249
PY - 2018
Y1 - 2018
N2 - Background/Aims: Exposure to obesity during pregnancy may lead to adverse changes in the offspring's metabolic profile. We compared appetite- and growth-related hormones in a cohort of infants born to obese mothers (SKOT-II) with infants born mainly to nonobese mothers (SKOT-I).Methods: Infants from SKOT-I (n = 273) and SKOT-II (n = 132) were examined including anthropometric measurements and blood samples analyzed for glucose, insulin, insulin-like growth factor-I (IGF-I), adiponectin, and leptin. Information on breastfeeding and parental characteristics were also collected.Results: At 9 months of age, SKOT-II infants were 3.6% heavier and 1.2% longer than SKOT-I infants even though their mothers were shorter. There was no difference in body mass index (BMI). SKOT-II infants had higher levels of insulin, adiponectin, and leptin but lower levels of IGF-I compared to SKOT-I infants (all p ≤ 0.015). These differences remained, except for leptin, when adjusted for current weight. Breastfeeding versus nonbreastfeeding at 9 months was associated with lower concentrations of all hormones (all p ≤ 0.003). In adjusted models, maternal BMI at 9 months was positively associated with insulin and adiponectin and negatively with IGF-I.Conclusions: Pre-pregnancy obesity confers symmetrically larger infant body size and higher levels of most growth- and appetite-related hormones but surprisingly lower levels of IGF-I, suggesting other possible infant growth-promoting effects through insulin.
AB - Background/Aims: Exposure to obesity during pregnancy may lead to adverse changes in the offspring's metabolic profile. We compared appetite- and growth-related hormones in a cohort of infants born to obese mothers (SKOT-II) with infants born mainly to nonobese mothers (SKOT-I).Methods: Infants from SKOT-I (n = 273) and SKOT-II (n = 132) were examined including anthropometric measurements and blood samples analyzed for glucose, insulin, insulin-like growth factor-I (IGF-I), adiponectin, and leptin. Information on breastfeeding and parental characteristics were also collected.Results: At 9 months of age, SKOT-II infants were 3.6% heavier and 1.2% longer than SKOT-I infants even though their mothers were shorter. There was no difference in body mass index (BMI). SKOT-II infants had higher levels of insulin, adiponectin, and leptin but lower levels of IGF-I compared to SKOT-I infants (all p ≤ 0.015). These differences remained, except for leptin, when adjusted for current weight. Breastfeeding versus nonbreastfeeding at 9 months was associated with lower concentrations of all hormones (all p ≤ 0.003). In adjusted models, maternal BMI at 9 months was positively associated with insulin and adiponectin and negatively with IGF-I.Conclusions: Pre-pregnancy obesity confers symmetrically larger infant body size and higher levels of most growth- and appetite-related hormones but surprisingly lower levels of IGF-I, suggesting other possible infant growth-promoting effects through insulin.
KW - Faculty of Science
KW - Pre-pregnancy obesity
KW - Infancy
KW - Insulin
KW - IGF-I
KW - Appetite
KW - Hormones
U2 - 10.1159/000490114
DO - 10.1159/000490114
M3 - Journal article
C2 - 29961064
VL - 90
SP - 28
EP - 38
JO - Hormone Research in Paediatrics
JF - Hormone Research in Paediatrics
SN - 1663-2818
IS - 1
ER -
ID: 200340574