The effect of praziquantel against Schistosoma mansoni-infections in Botswana
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The effect of praziquantel against Schistosoma mansoni-infections in Botswana. / Friis, H; Byskov, Jens.
In: Tropical and Geographical Medicine, Vol. 41, No. 1, 01.1989, p. 49-51.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of praziquantel against Schistosoma mansoni-infections in Botswana
AU - Friis, H
AU - Byskov, Jens
PY - 1989/1
Y1 - 1989/1
N2 - Chemotherapy of all infected individuals, using praziquantel 40 mg/kg in a single dose, was the initial component of the recently introduced control programme against Schistosoma mansoni-infections in Ngamiland, Botswana. To evaluate the effect of praziquantel in Ngamiland, 81 children were selected at random from three strata of intensities of infection. Six weeks after treatment a duplicate of Kato fecal thick smear was made. When eggs of S. mansoni were found, a new stool sample was collected and a hatching test performed. Only in case of a positive hatching test was the child considered to be infected: Cure rates between 78.6 and 90.0%, and reductions in egg output among noncured between 84.6 and 98.0% were found.
AB - Chemotherapy of all infected individuals, using praziquantel 40 mg/kg in a single dose, was the initial component of the recently introduced control programme against Schistosoma mansoni-infections in Ngamiland, Botswana. To evaluate the effect of praziquantel in Ngamiland, 81 children were selected at random from three strata of intensities of infection. Six weeks after treatment a duplicate of Kato fecal thick smear was made. When eggs of S. mansoni were found, a new stool sample was collected and a hatching test performed. Only in case of a positive hatching test was the child considered to be infected: Cure rates between 78.6 and 90.0%, and reductions in egg output among noncured between 84.6 and 98.0% were found.
KW - Animals
KW - Botswana
KW - Child
KW - Child, Preschool
KW - Clinical Trials as Topic
KW - Humans
KW - Parasite Egg Count
KW - Praziquantel
KW - Random Allocation
KW - Schistosomiasis mansoni
M3 - Journal article
C2 - 2503911
VL - 41
SP - 49
EP - 51
JO - Tropical and Geographical Medicine
JF - Tropical and Geographical Medicine
SN - 0041-3232
IS - 1
ER -
ID: 72804803