Putative factors that may modulate the effect of exercise on liver fat: insights from animal studies
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Putative factors that may modulate the effect of exercise on liver fat: insights from animal studies. / Magkos, Faidon.
In: Journal of Nutrition and Metabolism, Vol. 2012, 827417, 2012.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Putative factors that may modulate the effect of exercise on liver fat: insights from animal studies
AU - Magkos, Faidon
N1 - (Ekstern)
PY - 2012
Y1 - 2012
N2 - An increase in intrahepatic triglyceride (IHTG) content is the hallmark of nonalcoholic fatty liver disease (NAFLD) and is strongly associated with insulin resistance and dyslipidemia. Although regular aerobic exercise improves metabolic function, its role in regulating fat accumulation in the liver is incompletely understood, and human data are scarce. Results from exercise training studies in animals highlight a number of potential factors that could possibly mediate the effect of exercise on liver fat, but none of them has been formally tested in man. The effect of exercise on IHTG content strongly depends on the background diet, so that exercise is more effective in reducing IHTG under conditions that favor liver fat accretion (e.g., when animals are fed high-fat diets). Concurrent loss of body weight or visceral fat does not appear to mediate the effect of exercise on IHTG, whereas sex (males versus females), prandial status (fasted versus fed), and duration of training, as well as the time elapsed from the last bout of exercise could all be affecting the observed exercise-induced changes in IHTG content. The potential importance of these factors remains obscure, thus providing a wide array of opportunities for future research on the effects of exercise (and diet) on liver fat accumulation.
AB - An increase in intrahepatic triglyceride (IHTG) content is the hallmark of nonalcoholic fatty liver disease (NAFLD) and is strongly associated with insulin resistance and dyslipidemia. Although regular aerobic exercise improves metabolic function, its role in regulating fat accumulation in the liver is incompletely understood, and human data are scarce. Results from exercise training studies in animals highlight a number of potential factors that could possibly mediate the effect of exercise on liver fat, but none of them has been formally tested in man. The effect of exercise on IHTG content strongly depends on the background diet, so that exercise is more effective in reducing IHTG under conditions that favor liver fat accretion (e.g., when animals are fed high-fat diets). Concurrent loss of body weight or visceral fat does not appear to mediate the effect of exercise on IHTG, whereas sex (males versus females), prandial status (fasted versus fed), and duration of training, as well as the time elapsed from the last bout of exercise could all be affecting the observed exercise-induced changes in IHTG content. The potential importance of these factors remains obscure, thus providing a wide array of opportunities for future research on the effects of exercise (and diet) on liver fat accumulation.
U2 - 10.1155/2012/827417
DO - 10.1155/2012/827417
M3 - Review
C2 - 21912741
VL - 2012
JO - Journal of Nutrition and Metabolism
JF - Journal of Nutrition and Metabolism
SN - 2090-0724
M1 - 827417
ER -
ID: 290037222