Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women
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Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women. / Egeberg, Rikke; Olsen, Anja; Autrup, Herman; Christensen, Jane; Stripp, Connie; Tetens, Inge; Overvad, Kim; Tjønneland, Anne.
In: European Journal of Cancer Prevention, Vol. 17, No. 1, 2008, p. 39-47.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women
AU - Egeberg, Rikke
AU - Olsen, Anja
AU - Autrup, Herman
AU - Christensen, Jane
AU - Stripp, Connie
AU - Tetens, Inge
AU - Overvad, Kim
AU - Tjønneland, Anne
PY - 2008
Y1 - 2008
N2 - The aim of this study was to investigate whether polymorphisms in N-acetyl transferase 1 and 2 modify the association between meat consumption and risk of breast cancer. A nested case-control study was conducted among 24 697 postmenopausal women included in the 'Diet, Cancer and Health' cohort study (1993-2000). Three hundred and seventy-eight breast cancer cases were identified and matched to 378 controls. The incidence rate ratio (95% confidence interval) for breast cancer was 1.09 (1.02-1.17) for total meat, 1.15 (1.01-1.31) for red meat and 1.23 (1.04-1.45) for processed meat per 25 g daily increment in intake. Compared with slow acetylators, the IRR (95% confidence interval) among fast N-acetyl transferase 1 acetylators was 1.43 (1.03-1.99) and 1.13 (0.83-1.54) among intermediate/fast N-acetyl transferase 2 acetylators. Interaction analyses revealed that the positive associations between total meat intake and red meat intake and breast cancer risk were confined to intermediate/fast N-acetyl transferase 2 acetylators (Pinteraction = 0.03 and 0.04). Our findings support an association between meat consumption and breast cancer risk and that N-acetyl transferase 2 polymorphism has a modifying effect on the association, indicating that the association is confined to only genetically susceptible women.
AB - The aim of this study was to investigate whether polymorphisms in N-acetyl transferase 1 and 2 modify the association between meat consumption and risk of breast cancer. A nested case-control study was conducted among 24 697 postmenopausal women included in the 'Diet, Cancer and Health' cohort study (1993-2000). Three hundred and seventy-eight breast cancer cases were identified and matched to 378 controls. The incidence rate ratio (95% confidence interval) for breast cancer was 1.09 (1.02-1.17) for total meat, 1.15 (1.01-1.31) for red meat and 1.23 (1.04-1.45) for processed meat per 25 g daily increment in intake. Compared with slow acetylators, the IRR (95% confidence interval) among fast N-acetyl transferase 1 acetylators was 1.43 (1.03-1.99) and 1.13 (0.83-1.54) among intermediate/fast N-acetyl transferase 2 acetylators. Interaction analyses revealed that the positive associations between total meat intake and red meat intake and breast cancer risk were confined to intermediate/fast N-acetyl transferase 2 acetylators (Pinteraction = 0.03 and 0.04). Our findings support an association between meat consumption and breast cancer risk and that N-acetyl transferase 2 polymorphism has a modifying effect on the association, indicating that the association is confined to only genetically susceptible women.
KW - Arylamine N-Acetyltransferase
KW - Breast Neoplasms
KW - Case-Control Studies
KW - Cohort Studies
KW - Denmark
KW - Female
KW - Genotype
KW - Humans
KW - Isoenzymes
KW - Meat
KW - Middle Aged
KW - Polymorphism, Genetic
KW - Postmenopause
KW - Risk Factors
KW - Comparative Study
KW - Breast cancer
KW - Meat consumption
KW - NAT polymorphism
KW - Prospective cohort study
U2 - 10.1097/CEJ.0b013e32809b4cdd
DO - 10.1097/CEJ.0b013e32809b4cdd
M3 - Journal article
C2 - 18090909
VL - 17
SP - 39
EP - 47
JO - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
SN - 0959-8278
IS - 1
ER -
ID: 184389995