Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism. / Magkos, Faidon; Bradley, David; Schweitzer, George G; Finck, Brian N; Eagon, J Christopher; Ilkayeva, Olga; Newgard, Christopher B; Klein, Samuel.

In: Diabetes, Vol. 62, No. 8, 2013, p. 2757-2761.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Magkos, F, Bradley, D, Schweitzer, GG, Finck, BN, Eagon, JC, Ilkayeva, O, Newgard, CB & Klein, S 2013, 'Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism', Diabetes, vol. 62, no. 8, pp. 2757-2761. https://doi.org/10.2337/db13-0185

APA

Magkos, F., Bradley, D., Schweitzer, G. G., Finck, B. N., Eagon, J. C., Ilkayeva, O., Newgard, C. B., & Klein, S. (2013). Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism. Diabetes, 62(8), 2757-2761. https://doi.org/10.2337/db13-0185

Vancouver

Magkos F, Bradley D, Schweitzer GG, Finck BN, Eagon JC, Ilkayeva O et al. Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism. Diabetes. 2013;62(8):2757-2761. https://doi.org/10.2337/db13-0185

Author

Magkos, Faidon ; Bradley, David ; Schweitzer, George G ; Finck, Brian N ; Eagon, J Christopher ; Ilkayeva, Olga ; Newgard, Christopher B ; Klein, Samuel. / Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism. In: Diabetes. 2013 ; Vol. 62, No. 8. pp. 2757-2761.

Bibtex

@article{cc8fc75af3f74b16927f9a8ba485611d,
title = "Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism",
abstract = "It has been hypothesized that a greater decline in circulating branched-chain amino acids (BCAAs) after weight loss induced by Roux-en-Y gastric bypass (RYGB) surgery than after calorie restriction alone has independent effects on glucose homeostasis, possibly by decreased signaling through the mammalian target of rapamycin (mTOR). We evaluated plasma BCAAs and their C3 and C5 acylcarnitine metabolites, muscle mTOR phosphorylation, and insulin sensitivity (insulin-stimulated glucose Rd) in obese subjects before and after ~20% weight loss induced by RYGB (n = 10, BMI 45.6 ± 6.7 kg/m(2)) or laparoscopic adjustable gastric banding (LAGB) (n = 10, BMI 46.5 ± 8.8 kg/m(2)). Weight loss increased insulin-stimulated glucose Rd by ~55%, decreased total plasma BCAA and C3 and C5 acylcarnitine concentrations by 20-35%, and did not alter mTOR phosphorylation; no differences were detected between surgical groups (all P values for interaction >0.05). Insulin-stimulated glucose Rd correlated negatively with plasma BCAAs and with C3 and C5 acylcarnitine concentrations (r values -0.56 to -0.75, P < 0.05). These data demonstrate that weight loss induced by either LAGB or RYGB causes the same decline in circulating BCAAs and their C3 and C5 acylcarnitine metabolites. Plasma BCAA concentration is negatively associated with skeletal muscle insulin sensitivity, but the mechanism(s) responsible for this relationship is not known.",
keywords = "Adult, Amino Acids, Branched-Chain/metabolism, Blood Glucose/metabolism, Caloric Restriction, Female, Gastric Bypass, Gastroplasty, Humans, Insulin/pharmacology, Insulin Resistance, Laparoscopy, Male, Muscle, Skeletal/metabolism, Obesity/metabolism, Phosphorylation, TOR Serine-Threonine Kinases/metabolism",
author = "Faidon Magkos and David Bradley and Schweitzer, {George G} and Finck, {Brian N} and Eagon, {J Christopher} and Olga Ilkayeva and Newgard, {Christopher B} and Samuel Klein",
note = "(Ekstern)",
year = "2013",
doi = "10.2337/db13-0185",
language = "English",
volume = "62",
pages = "2757--2761",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "8",

}

RIS

TY - JOUR

T1 - Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism

AU - Magkos, Faidon

AU - Bradley, David

AU - Schweitzer, George G

AU - Finck, Brian N

AU - Eagon, J Christopher

AU - Ilkayeva, Olga

AU - Newgard, Christopher B

AU - Klein, Samuel

N1 - (Ekstern)

PY - 2013

Y1 - 2013

N2 - It has been hypothesized that a greater decline in circulating branched-chain amino acids (BCAAs) after weight loss induced by Roux-en-Y gastric bypass (RYGB) surgery than after calorie restriction alone has independent effects on glucose homeostasis, possibly by decreased signaling through the mammalian target of rapamycin (mTOR). We evaluated plasma BCAAs and their C3 and C5 acylcarnitine metabolites, muscle mTOR phosphorylation, and insulin sensitivity (insulin-stimulated glucose Rd) in obese subjects before and after ~20% weight loss induced by RYGB (n = 10, BMI 45.6 ± 6.7 kg/m(2)) or laparoscopic adjustable gastric banding (LAGB) (n = 10, BMI 46.5 ± 8.8 kg/m(2)). Weight loss increased insulin-stimulated glucose Rd by ~55%, decreased total plasma BCAA and C3 and C5 acylcarnitine concentrations by 20-35%, and did not alter mTOR phosphorylation; no differences were detected between surgical groups (all P values for interaction >0.05). Insulin-stimulated glucose Rd correlated negatively with plasma BCAAs and with C3 and C5 acylcarnitine concentrations (r values -0.56 to -0.75, P < 0.05). These data demonstrate that weight loss induced by either LAGB or RYGB causes the same decline in circulating BCAAs and their C3 and C5 acylcarnitine metabolites. Plasma BCAA concentration is negatively associated with skeletal muscle insulin sensitivity, but the mechanism(s) responsible for this relationship is not known.

AB - It has been hypothesized that a greater decline in circulating branched-chain amino acids (BCAAs) after weight loss induced by Roux-en-Y gastric bypass (RYGB) surgery than after calorie restriction alone has independent effects on glucose homeostasis, possibly by decreased signaling through the mammalian target of rapamycin (mTOR). We evaluated plasma BCAAs and their C3 and C5 acylcarnitine metabolites, muscle mTOR phosphorylation, and insulin sensitivity (insulin-stimulated glucose Rd) in obese subjects before and after ~20% weight loss induced by RYGB (n = 10, BMI 45.6 ± 6.7 kg/m(2)) or laparoscopic adjustable gastric banding (LAGB) (n = 10, BMI 46.5 ± 8.8 kg/m(2)). Weight loss increased insulin-stimulated glucose Rd by ~55%, decreased total plasma BCAA and C3 and C5 acylcarnitine concentrations by 20-35%, and did not alter mTOR phosphorylation; no differences were detected between surgical groups (all P values for interaction >0.05). Insulin-stimulated glucose Rd correlated negatively with plasma BCAAs and with C3 and C5 acylcarnitine concentrations (r values -0.56 to -0.75, P < 0.05). These data demonstrate that weight loss induced by either LAGB or RYGB causes the same decline in circulating BCAAs and their C3 and C5 acylcarnitine metabolites. Plasma BCAA concentration is negatively associated with skeletal muscle insulin sensitivity, but the mechanism(s) responsible for this relationship is not known.

KW - Adult

KW - Amino Acids, Branched-Chain/metabolism

KW - Blood Glucose/metabolism

KW - Caloric Restriction

KW - Female

KW - Gastric Bypass

KW - Gastroplasty

KW - Humans

KW - Insulin/pharmacology

KW - Insulin Resistance

KW - Laparoscopy

KW - Male

KW - Muscle, Skeletal/metabolism

KW - Obesity/metabolism

KW - Phosphorylation

KW - TOR Serine-Threonine Kinases/metabolism

U2 - 10.2337/db13-0185

DO - 10.2337/db13-0185

M3 - Journal article

C2 - 23610059

VL - 62

SP - 2757

EP - 2761

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 8

ER -

ID: 289967843