Drug-induced hepatic injury: an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Drug-induced hepatic injury : an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987. / Friis, Henrik; Andreasen, P B.
In: Journal of Internal Medicine, Vol. 232, No. 2, 08.1992, p. 133-138.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Drug-induced hepatic injury
T2 - an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987
AU - Friis, Henrik
AU - Andreasen, P B
PY - 1992/8
Y1 - 1992/8
N2 - The Danish Committee on Adverse Drug Reactions received 1100 reports of suspected drug-induced hepatic injury during the decade 1978-1987. The causal relationship between drug and hepatic injury was classified as definite in 57 (5.2%) reports, probable in 989 (89.9%) reports, possible in 50 (4.5%) reports and unclassifiable in four (0.4%) reports. Hepatic injuries accounted for 5.9% of all adverse drug reactions reported, and 14.7% of the lethal adverse drug reactions. A total of 47.2% were classified as acute cytotoxic, 16.2% as acute cholestatic and 26.9% as abnormal hepatic function. In 52 (4.7%) cases the hepatic injury was lethal; only 14 (1.3%) cases were chronic. Halothane accounted for 25% of the cases. The incidence of halothane-induced hepatic injury is decreasing, and only one lethal case has been reported since 1981. Next to halothane, sulfasalazine was the drug most often suspected during the last 2 years of the decade. Based on consumption data, the incidence of hepatic injury due to sulindac was estimated to be 18-fold higher than that due to ibuprofen. Paracetamol was reported to induce acute cytotoxic as well as cholestatic reactions in non-alcoholic subjects taking therapeutic doses.
AB - The Danish Committee on Adverse Drug Reactions received 1100 reports of suspected drug-induced hepatic injury during the decade 1978-1987. The causal relationship between drug and hepatic injury was classified as definite in 57 (5.2%) reports, probable in 989 (89.9%) reports, possible in 50 (4.5%) reports and unclassifiable in four (0.4%) reports. Hepatic injuries accounted for 5.9% of all adverse drug reactions reported, and 14.7% of the lethal adverse drug reactions. A total of 47.2% were classified as acute cytotoxic, 16.2% as acute cholestatic and 26.9% as abnormal hepatic function. In 52 (4.7%) cases the hepatic injury was lethal; only 14 (1.3%) cases were chronic. Halothane accounted for 25% of the cases. The incidence of halothane-induced hepatic injury is decreasing, and only one lethal case has been reported since 1981. Next to halothane, sulfasalazine was the drug most often suspected during the last 2 years of the decade. Based on consumption data, the incidence of hepatic injury due to sulindac was estimated to be 18-fold higher than that due to ibuprofen. Paracetamol was reported to induce acute cytotoxic as well as cholestatic reactions in non-alcoholic subjects taking therapeutic doses.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Alkaline Phosphatase
KW - Child
KW - Child, Preschool
KW - Clinical Enzyme Tests
KW - Denmark
KW - Drug-Induced Liver Injury
KW - Female
KW - Humans
KW - Infant
KW - Liver Diseases
KW - Liver Function Tests
KW - Male
KW - Middle Aged
KW - Transaminases
M3 - Journal article
C2 - 1506809
VL - 232
SP - 133
EP - 138
JO - Acta Medica Scandinavica
JF - Acta Medica Scandinavica
SN - 0955-7873
IS - 2
ER -
ID: 119653605