Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › fagfællebedømt

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Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort. / Borgers, J. S.W.; Burgers, F. H.; Schina, A.; Van Not, O. J.; van den Eertwegh, A. J.M.; Blank, C. U.; Aarts, M. J.B.; van den Berkmortel, F. W.P.J.; de Groot, J. W.B.; Hospers, G. A.P.; Kapiteijn, E.; Piersma, D.; van Rijn, R. S.; Boer, A. M.Stevense den; van der Veldt, A. A.M.; Vreugdenhil, G.; Boers-Sonderen, M. J.; Wouters, M. W.J.M.; Suijkerbuijk, K. P.M.; van Thienen, J. V.; Haanen, J. B.A.G.

I: Pigment Cell and Melanoma Research, Bind 37, Nr. 1, 2024.

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › fagfællebedømt

Harvard

Borgers, JSW, Burgers, FH, Schina, A, Van Not, OJ, van den Eertwegh, AJM, Blank, CU, Aarts, MJB, van den Berkmortel, FWPJ, de Groot, JWB, Hospers, GAP, Kapiteijn, E, Piersma, D, van Rijn, RS, Boer, AMSD, van der Veldt, AAM, Vreugdenhil, G, Boers-Sonderen, MJ, Wouters, MWJM, Suijkerbuijk, KPM, van Thienen, JV & Haanen, JBAG 2024, 'Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort', Pigment Cell and Melanoma Research, bind 37, nr. 1. https://doi.org/10.1111/pcmr.13117

APA

Borgers, J. S. W., Burgers, F. H., Schina, A., Van Not, O. J., van den Eertwegh, A. J. M., Blank, C. U., Aarts, M. J. B., van den Berkmortel, F. W. P. J., de Groot, J. W. B., Hospers, G. A. P., Kapiteijn, E., Piersma, D., van Rijn, R. S., Boer, A. M. S. D., van der Veldt, A. A. M., Vreugdenhil, G., Boers-Sonderen, M. J., Wouters, M. W. J. M., Suijkerbuijk, K. P. M., ... Haanen, J. B. A. G. (2024). Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort. Pigment Cell and Melanoma Research, 37(1). https://doi.org/10.1111/pcmr.13117

Vancouver

Borgers JSW, Burgers FH, Schina A, Van Not OJ, van den Eertwegh AJM, Blank CU o.a. Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort. Pigment Cell and Melanoma Research. 2024;37(1). https://doi.org/10.1111/pcmr.13117

Author

Borgers, J. S.W. ; Burgers, F. H. ; Schina, A. ; Van Not, O. J. ; van den Eertwegh, A. J.M. ; Blank, C. U. ; Aarts, M. J.B. ; van den Berkmortel, F. W.P.J. ; de Groot, J. W.B. ; Hospers, G. A.P. ; Kapiteijn, E. ; Piersma, D. ; van Rijn, R. S. ; Boer, A. M.Stevense den ; van der Veldt, A. A.M. ; Vreugdenhil, G. ; Boers-Sonderen, M. J. ; Wouters, M. W.J.M. ; Suijkerbuijk, K. P.M. ; van Thienen, J. V. ; Haanen, J. B.A.G. / Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort. I: Pigment Cell and Melanoma Research. 2024 ; Bind 37, Nr. 1.

Bibtex

@article{049658060b364f1485a5d0c0b4971414,
title = "Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort",
abstract = "Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment.",
author = "Borgers, {J. S.W.} and Burgers, {F. H.} and A. Schina and Van Not, {O. J.} and {van den Eertwegh}, {A. J.M.} and Blank, {C. U.} and Aarts, {M. J.B.} and {van den Berkmortel}, {F. W.P.J.} and {de Groot}, {J. W.B.} and Hospers, {G. A.P.} and E. Kapiteijn and D. Piersma and {van Rijn}, {R. S.} and Boer, {A. M.Stevense den} and {van der Veldt}, {A. A.M.} and G. Vreugdenhil and Boers-Sonderen, {M. J.} and Wouters, {M. W.J.M.} and Suijkerbuijk, {K. P.M.} and {van Thienen}, {J. V.} and Haanen, {J. B.A.G.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Pigment Cell & Melanoma Research published by John Wiley & Sons Ltd.",
year = "2024",
doi = "10.1111/pcmr.13117",
language = "English",
volume = "37",
journal = "Pigment Cell & Melanoma Research",
issn = "1755-1471",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort

AU - Borgers, J. S.W.

AU - Burgers, F. H.

AU - Schina, A.

AU - Van Not, O. J.

AU - van den Eertwegh, A. J.M.

AU - Blank, C. U.

AU - Aarts, M. J.B.

AU - van den Berkmortel, F. W.P.J.

AU - de Groot, J. W.B.

AU - Hospers, G. A.P.

AU - Kapiteijn, E.

AU - Piersma, D.

AU - van Rijn, R. S.

AU - Boer, A. M.Stevense den

AU - van der Veldt, A. A.M.

AU - Vreugdenhil, G.

AU - Boers-Sonderen, M. J.

AU - Wouters, M. W.J.M.

AU - Suijkerbuijk, K. P.M.

AU - van Thienen, J. V.

AU - Haanen, J. B.A.G.

N1 - Publisher Copyright: © 2023 The Authors. Pigment Cell & Melanoma Research published by John Wiley & Sons Ltd.

PY - 2024

Y1 - 2024

N2 - Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment.

AB - Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment.

U2 - 10.1111/pcmr.13117

DO - 10.1111/pcmr.13117

M3 - Comment/debate

C2 - 37554041

AN - SCOPUS:85167368040

VL - 37

JO - Pigment Cell & Melanoma Research

JF - Pigment Cell & Melanoma Research

SN - 1755-1471

IS - 1

ER -

ID: 372824018