p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these two apparently opposing models, demonstrating that pancreatic progenitors re-localize to establish the niche that will determine their ultimate fate. We identify a p120ctn-regulated mechanism for coordination of organ architecture and cellular fate mediated by differential E-cadherin based cell sorting. Reduced p120ctn expression is necessary and sufficient to re-localize a subset of progenitors to the peripheral tip domain, where they acquire an acinar fate. The same mechanism is used re-iteratively during endocrine specification, where it balances the choice between the alpha and beta cell fates. In conclusion, organ patterning is regulated by p120ctn-mediated cellular positioning, which precedes and determines pancreatic progenitor fate.
Originalsprog | Engelsk |
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Tidsskrift | Developmental Cell |
Vol/bind | 49 |
Udgave nummer | 1 |
Sider (fra-til) | 31-47.e9 |
ISSN | 1534-5807 |
DOI | |
Status | Udgivet - 8 apr. 2019 |
Bibliografisk note
Copyright © 2019 Elsevier Inc. All rights reserved.
ID: 226495164