Histochemical studies on genetical control of hormonal enzyme inducibility in the mouse. IV: Cellular localization of androgen sensitive nonspecific esterase in the epididymis
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Histochemical studies on genetical control of hormonal enzyme inducibility in the mouse. IV: Cellular localization of androgen sensitive nonspecific esterase in the epididymis. / Kirkeby, S; Blecher, S R.
I: Archives of Andrology, Bind 6, Nr. 2, 1981, s. 163-73.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Histochemical studies on genetical control of hormonal enzyme inducibility in the mouse. IV: Cellular localization of androgen sensitive nonspecific esterase in the epididymis
AU - Kirkeby, S
AU - Blecher, S R
N1 - Keywords: Androgens; Animals; Castration; Contraceptive Agents, Male; Cyproterone; Cyproterone Acetate; Epididymis; Esterases; Histocytochemistry; Male; Mice; Mice, Inbred Strains; Species Specificity
PY - 1981
Y1 - 1981
N2 - Nonspecific esterase of mouse epididymis has previously been studied histochemically, using alpha naphthyl-acetate and 5-bromoindoxyl acetate techniques, as well as certain inhibitors. Epithelial cell types of the epididymis have been characterized, and certain esterase isozymes in a particular cell type, is shown to be androgen dependent. When mice of different strains were castrated or treated with antiandrogens, the characteristic histochemical reaction product disappeared or was greatly reduced. Androgen treatment of castrated animals caused the reaction in the cells concerned to return to normal. This method can now be applied to the study of epididymides of genetically sex-reversed chromosomal female, to analyze genetic control of X-chromosomal activation.
AB - Nonspecific esterase of mouse epididymis has previously been studied histochemically, using alpha naphthyl-acetate and 5-bromoindoxyl acetate techniques, as well as certain inhibitors. Epithelial cell types of the epididymis have been characterized, and certain esterase isozymes in a particular cell type, is shown to be androgen dependent. When mice of different strains were castrated or treated with antiandrogens, the characteristic histochemical reaction product disappeared or was greatly reduced. Androgen treatment of castrated animals caused the reaction in the cells concerned to return to normal. This method can now be applied to the study of epididymides of genetically sex-reversed chromosomal female, to analyze genetic control of X-chromosomal activation.
M3 - Journal article
C2 - 6454401
VL - 6
SP - 163
EP - 173
JO - Systems Biology in Reproductive Medicine
JF - Systems Biology in Reproductive Medicine
SN - 1939-6368
IS - 2
ER -
ID: 10209992