5-Benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Herein we outline the antibacterial activity of amino acid containing thiazolidinediones and rhodanines against Gram-positive bacteria Staphylococcus aureus ATCC 31890, Staphylococcus epidermidis and Bacillus subtilis ATCC 6633. The rhodanine derivatives were generally more active than the analogous thiazolidinediones. Compounds of series 5 showed some selectivity for Bacillus subtilis ATCC 6633, the extent of which is enhanced by the inclusion of a non-polar amino acid at the 5-position of the core thiazolidinediones and rhodanines scaffolds. SAR data of series 8 demonstrated improved activity against the clinically more significant Staphylococci with selectivity over Bacillus subtilis ATCC 6633 induced by introduction of a bulky aryl substituent at the 5-position of the core scaffolds.
Originalsprog | Engelsk |
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Tidsskrift | Bioorganic & Medicinal Chemistry Letters |
Vol/bind | 22 |
Udgave nummer | 8 |
Sider (fra-til) | 2720-2722 |
Antal sider | 3 |
ISSN | 0960-894X |
DOI | |
Status | Udgivet - 15 apr. 2012 |
Eksternt udgivet | Ja |
ID: 49635537