25CN-NBOH: A selective agonist for in vitro and in vivo investigations of the serotonin 2A receptor
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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4-(2-((2-hydroxybenzyl)amino)ethyl)-2,5-dimethoxybenzonitrile (25CN-NBOH) was first reported as a potent and selective serotonin 2A receptor (5-HT 2A R) agonist in 2014, and it has since found extensive use as a pharmacological tool in a variety of in vitro, ex vivo and in vivo studies. 25CN-NBOH is readily available from a synthetic perspective using standard chemical transformations, and displays favorable physiochemical properties in terms of stability and solubility. Due to its superior selectivity for 5-HT 2A R, 25CN-NBOH has been used to investigate the effects of selective 5-HT 2A R activation in vivo, and has thus become an important pharmacological tool for the exploration of 5-HT 2A R signaling in a range of animal models. In the present review, we outline the discovery of 25CN-NBOH, its pharmacological profile and major findings from studies where it has been used.
Originalsprog | Engelsk |
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Tidsskrift | ChemMedChem |
Vol/bind | 16 |
Udgave nummer | 21 |
Sider (fra-til) | 3263-3270 |
ISSN | 1860-7179 |
DOI | |
Status | Udgivet - 2021 |
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