11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Small-molecule a(7) nicotinic acetylcholine receptor (a(7)nAChR) agonists are currently validated for use as treatment for cognitive disturbances in schizophrenia and in Alzheimer disease. A suitable radiolabeled a(7)nAChR PET tracer would be important for in vivo quantification of a(7)nAChR binding in humans and to measure a(7)nAChR occupancy of a(7)nAChR drug candidates. Here, we present the radiosynthesis and in vivo evaluation of (11)C-NS14492 as a selective a(7)nAChR PET radioligand.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Nuclear Medicine |
| Vol/bind | 52 |
| Udgave nummer | 9 |
| Sider (fra-til) | 1449-56 |
| Antal sider | 8 |
| ISSN | 0161-5505 |
| DOI | |
| Status | Udgivet - 2011 |
ID: 40216005